Ormosil

Under Ormosil refers organically modified silica or organically modified silicate . This is an acronym of the English language: Or ganically Mo dified Sil icate . This term encompasses materials that are extremely promising for a large number of applications, for example:

as an alternative to viral vectors for gene transfer, which is characterized by a higher transient transfection efficiency.
as suspending agents and substrates for the next innovative generation of solar cells ( quantum dots )
as a matrix material for UV protection coatings
as a matrix material for laser-dye-doped organic-inorganic solid-state dye lasers

This technique has been shown to be a non-viral vector to successfully deliver loads of DNA to specifically labeled cells in living animals. Confirmation of the results showed that new DNA was functional and expressing genes in the animal.

Precursors for such particles are numerous monosubstituted siloxanes such as vinyltrimethoxysilane .

Sono-Ormosil

As a Sono-ormosils be organically modified silicates ( or ganically mo dified sil icates) indicated that by the use of high-performance ultrasound are generated. If ultrasound of high intensity is introduced into liquid, cavitation is generated. The shear forces generated by cavitation lead to a lowering of the molar mass due to particle size reduction and to polydispersity. Multi-phase systems are dispersed and emulsified very efficiently, so that very fine mixtures are produced. This means that ultrasound significantly accelerates the polymerization compared to conventional stirring. The resulting polymer has a higher molar mass with a lower polydispersity. The product is a molecular-scale composite material with improved mechanical properties. Compared to classic gels, Sono-Ormosils are characterized by a higher density and improved thermal stability. One explanation for this could be the increased degree of polymerization.

Individual evidence

↑ Chia-Yen Li, Justine Y. Tseng, Kazuki Morita, CL Lechner, Yi Hu, John D. Mackenzie: ORMOSILS as matrices in inorganic-organic nanocomposites for various optical applications . In: Proc. SPIE . Vol. 1758, Sol-Gel Optics II, December 7, 1992, pp. 410-419 , doi : 10.1117 / 12.132033 .
↑ Ellen Goldbaum: Using nanoparticles, in vivo gene therapy activates brain stem cells. In: Medical News Today. July 26, 2005, accessed March 28, 2013 .
↑ Ultrasonic synthesis of silver nanoparticles. hielscher.com, accessed on February 11, 2016 .
↑ Rosa-Fox, N. de la; Pinero, M .; Esquivias, L. (2002): Organic-Inorganic Hybrid Materials from Sonogels. 2002.

[1] Chia-Yen Li, Justine Y. Tseng, Kazuki Morita, CL Lechner, Yi Hu, John D. Mackenzie: ORMOSILS as matrices in inorganic-organic nanocomposites for various optical applications . In: Proc. SPIE . Vol. 1758, Sol-Gel Optics II, December 7, 1992, pp. 410-419 , doi : 10.1117 / 12.132033 .

[2] Ellen Goldbaum: Using nanoparticles, in vivo gene therapy activates brain stem cells. In: Medical News Today. July 26, 2005, accessed March 28, 2013 .

[3] Ultrasonic synthesis of silver nanoparticles. hielscher.com, accessed on February 11, 2016 .

[4] Rosa-Fox, N. de la; Pinero, M .; Esquivias, L. (2002): Organic-Inorganic Hybrid Materials from Sonogels. 2002.