Ostitis fibrosa cystica

Classification according to ICD-10
E21.0	Osteodystrophia fibrosa cystica generalisata
ICD-10 online (WHO version 2019)

Osteitis fibrosa cystica of the tibia .

The osteitis fibrosa cystica Generalisata (also: von Recklinghausen's disease of bone , short Recklinghausen's disease , but not to be confused with neurofibromatosis type I, von Recklinghausen ), also briefly osteitis fibrosa called, arises as a result of an overactive parathyroid glands ( hyperparathyroidism ) .

The increased parathyroid hormone concentration in the blood stimulates osteoclasts , which break down bone substance. The degraded material is replaced by connective tissue (fibroosteoclasia). If the disease progresses, “brown tumors” can develop in the late stages, which are typical of ostitis fibrosa cystica generalisata. They arise from bleeding into areas of the bone that has been converted into connective tissue and can be seen as cyst-like structures in and on bones.

classification

Ostitis fibrosa (cystica) generalisata is defined as the classic consequence of persistent hyperparathyroidism and is classified in the ICD-10 in category E21.0 (primary hyperparathyroidism).

Differential diagnoses

• sarcoma

literature

• Karlheinz Schleicher: About a case of "Ostitis fibrosa cystica generalisata" v. Recklinghausen in connection with signs of intestinal infantilism. Dissertation . Freiburg i. Br. 1941.
• Hans Rudolf Berndorff : Tryst with death. A forgotten episode from Sauerbruch's life. In: Ferdinand Sauerbruch : That was my life. (1951) 1956, pp. 439–456, here: pp. 448–455 (including the possibility of confusing “Recklinghausen” with a sarcoma, which is why unnecessary amputations were often performed).
• Ludwig Weissbecker: Hyperparathyroidism (Ostitis fibrosa generalisata, Recklinghausen's disease). In: Ludwig Heilmeyer (ed.): Textbook of internal medicine. Springer-Verlag, Berlin / Göttingen / Heidelberg 1955; 2nd edition, ibid. 1961, pp. 1057-1060.

Web links

• Entry in online medical dictionary

Individual evidence

1. ^ Walter Siegenthaler: Clinical Pathophysiology. 2006, ISBN 3-13-449609-7 , p. 304.
2. ↑ ICD-Code.de: E21. Hyperparathyroidism and other diseases of the parathyroid gland
3. ↑ About a case of "Ostitis fibrosa cystica generalisata" v. Recklinghausen in connection with signs of intestinal infantilism on Google Books

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !