PAZ domain

A PAZ domain is a protein domain . PAZ-domains are about 110 amino acid - monomers long. The name is derived from the three proteins in which the domain was first found: Piwi , Argonaut and Zwille / Pinhead. The PAZ domain occurs in the Argonaute and Dicer protein families , both of which are involved in post-translational gene silencing ( PTGS - for example, post-transcriptional gene shutdown) through RNA interference ( RNAi ).

The PAZ domain contains an OB fold , which is responsible for the nucleic acid interaction of Argonaute and Dicer . The PAZ domain probably interacts with the 3 'end of the si- or miRNA ( microRNA , small RNA ).

Web link

Swiss Institute of Bioinformatics (SIB): PROSITE documentation PDOC50821. Retrieved September 26, 2011 .

Individual evidence

↑ Song JJ, Liu J, Tolia NH, ao: The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes . (PDF) In: Nat. Struct. Biol . 10, No. 12, December 2003, pp. 1026-32. doi : 10.1038 / nsb1016 . PMID 14625589 .

[1] Song JJ, Liu J, Tolia NH, ao: The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes . (PDF) In: Nat. Struct. Biol . 10, No. 12, December 2003, pp. 1026-32. doi : 10.1038 / nsb1016 . PMID 14625589 .