PDE-4 inhibitors

Phosphodiesterase-4 inhibitors (also phosphodiesterase-IV-inhibitors , PDE-4-inhibitors ) are substances that inhibit the enzyme phosphodiesterase-IV . Phosphodiesterase IV breaks down the second messenger cAMP . PDE-4 inhibitors therefore increase the concentration of intracellular cAMP. The enzyme is found in the lungs, among other things.

The prototype of the phosphodiesterase 4 inhibitor is rolipram . PDE-4 inhibitors have anti-inflammatory effects and have been a. investigated in the areas of application of COPD , bronchial asthma , depression and multiple sclerosis . So far, two active ingredients have been approved as medicinal products: roflumilast (Daxas ^® ) and apremilast (Otezla ^® ). The development of cipamfylline has been discontinued.

literature

• BM Gensthaler: PDE-4 inhibitors against COPD and asthma , Pharmazeutische Zeitung 14 (2003)

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