PEST sequence

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PEST sequences are parts of proteins that are particularly rich in the amino acids proline ( P ), glutamate ( E ), serine ( S ) and threonine ( T ), which leads to a shorter half-life t 1/2 of the entire protein and thus to a faster breakdown in the proteasome . They are contained in androgen , estrogen and vitamin D receptors , among other things . The activity of PEST sequences is regulated by phosphorylation of neighboring domains .

See also

Sequence motif


  • David P. Clark, Nanette Pazdernik: Molecular Biotechnology: Fundamentals and Applications . 2008. S. 302f., ( Online in the Google book search)

Individual evidence

  1. Georg Löffler, Peter C. Heinrich, Petro E. Petrides (Eds.): Biochemistry and Pathobiochemistry . Springer, Heidelberg 2007, ISBN 978-3-540-32680-9 , pp. 321 f .