PK / PD modeling

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The PK / PD modeling (also PK-PD modeling , engl. PK / PD modeling ) included in the pharmacology methods of drug design , showing the pharmacokinetics and pharmacodynamics for the calculation of the time course of action in response to the administration of a dose use.

There are different calculation approaches, which are divided into five classes:

  • Direct link PK / PD models
  • Indirect link PK / PD models
  • Indirect response PK / PD models
  • Cell Lifespan models
  • Complex response models

Individual evidence

  1. ^ JO Hahn, S. Khosravi, GA Dumont, JM Ansermino: Two-stage vs mixed-effect approach to pharmacodynamic modeling of propofol in children using state entropy. In: Pediatr Anaesth. (2011), Volume 21, No. 6, pp. 691-698. doi : 10.1111 / j.1460-9592.2011.03584.x . PMID 21518104 .
  2. ^ S. Goutelle, M. Maurin, F. Rougier, X. Barbaut, L. Bourguignon, M. Ducher, P. Maire: The Hill equation: a review of its capabilities in pharmacological modeling. In: Fundam Clin Pharmacol . (2008), Vol. 22, No. 6, pp. 633-648. doi : 10.1111 / j.1472-8206.2008.00633.x . PMID 19049668 .
  3. ↑ H. Derendorf, B. Meibohm: Modeling of pharmacokinetic / pharmacodynamic (PK / PD) relationships: concepts and perspectives. In: Pharm Res . (1999), Vol. 16, No. 2, pp. 176-185. PMID 10100300 .
  4. ↑ Daan Crommelin, Bernd Meibohm, Robert Sindelar: Pharmaceutical Biotechnology: Fundamentals and Applications. 3rd edition, Informa Healthcare, 2007. ISBN 9781420044379 .