Platelet adhesion

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The platelet describes an early process of the cellular mediated blood coagulation , which serves to close a wound and the stop the bleeding.

Thrombocytes (blood platelets) adhere to a surface with which they normally do not come into contact within intact blood vessels. If the vessels are injured, these are components of the tissue behind the vessel (sub- endothelium ). This adhesion is a prerequisite for platelet aggregation , which is essential for sealing injured blood vessels.

Experiments have shown that platelets can also adhere to inorganic materials such as glass, porcelain or metal. The adhesion to defined glass surfaces is used to determine the adhesiveness of platelets. Disturbances in platelet adhesion can lead to severely delayed bleeding in the event of injuries. The Rumpel-Leede test can be used to examine the platelet function in the patient. However, this test cannot clarify which part of the cell-mediated blood coagulation is disrupted, for example, when the bleeding time is prolonged.

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  • RK Andrews, MC Berndt: Platelet adhesion: a game of catch and release. In: J. Clin. Invest. 118 (9), 2008, pp. 3009-3011. PMID 18725992 , PMC 2518077 (free full text)