Posterior Fossa Syndrome

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Classification according to ICD-10
Z98.8 Other specified conditions following surgery
ICD-10 online (WHO version 2019)

The posterior fossa syndrome is a combination of cerebellum -bedingtem (cerebellar) mutism (CM) and behavioral changes as a complication after operation of a brain tumor of the posterior fossa (posterior fossa).

Synonyms are: posterior fossa syndrome; Posterior fossa syndrome (FPS); English Cerebellar Mutism Syndrome (CMS)

The first description comes from 1979 by JF Hirsch and colleagues.

The term "cerebral mutism" was coined by Harold L. Rekate and co-workers in 1985.

Occurrence

The posterior fossa syndrome can occur in 15–25% of cases after surgical removal of a tumor from the posterior fossa; it usually affects children and women are more often affected.

Other less common causes can be trauma , stroke, or infection . Only individual cases have been described in adults.

Clinical manifestations

Clinical criteria are:

  • Occurs 1 - 2 days or 1 week after the operation
  • Loss or impairment of speech when fully conscious (mutism)
  • Complete, sometimes only slow (months - years) normalization

In addition, there may be autism , paralysis , disorders of the sense of balance or urination, or other behavioral problems .

literature

  • JE Schreiber, SL Palmer, HM Conklin, DJ Mabbott, MA Swain, MJ Bonner, ML Chapieski, L. Huang, H. Zhang, A. Gajjar: Posterior fossa syndrome and long-term neuropsychological outcomes among children treated for medulloblastoma on a multi -institutional, prospective study. In: Neuro-oncology. Vol. 19, No. 12, November 2017, pp. 1673–1682, doi: 10.1093 / neuonc / nox135 , PMID 29016818 , PMC 5716082 (free full text).
  • JC Lanier, AN Abrams: Posterior fossa syndrome: Review of the behavioral and emotional aspects in pediatric cancer patients. In: Cancer. Vol. 123, No. 4, February 2017, pp. 551-559, doi: 10.1002 / cncr.30238 , PMID 27787875 (Review).
  • EA Kirk, VC Howard, CA Scott: Description of posterior fossa syndrome in children after posterior fossa brain tumor surgery. In: Journal of pediatric oncology nursing: official journal of the Association of Pediatric Oncology Nurses. Vol. 12, No. 4, October 1995, pp. 181-187, doi: 10.1177 / 104345429501200402 , PMID 7495523 .
  • IF Pollack: Posterior fossa syndrome. In: International review of neurobiology. Vol. 41, 1997, pp. 411-432, PMID 9378600 .

Individual evidence

  1. ↑ E. Knapitsch, M. Hamberger, K. Nussbaumer, T. Narovec et al .: Fossa Posterior Syndrome: Cerebellar Mutism after Cerebellar Hemorrhage - Case Report and Review of the Literature In: Journal of Neurology, Neurosurgery and Psychiatry Vol. 9, No. 2, 2008, pp. 38–42, [1]
  2. ↑ JF Hirsch, D. Renier, P. Czernichow, L. Benveniste, A. Pierre-Kahn: Medulloblastoma in childhood. Survival and functional results. In: Acta neurochirurgica. Vol. 48, No. 1-2, 1979, pp. 1-15, PMID 495234 .
  3. Jump up ↑ HL Rekate, RL Grubb, DM Aram, JF Hahn, RA Ratcheson: Muteness of cerebellar origin. In: Archives of neurology. Vol. 42, No. 7, July 1985, pp. 697-698, PMID 4015467 .
  4. ↑ a b Children's cancer info
  5. ^ A b N. Gadgil, D. Hansen, J. Barry, R. Chang, S. Lam: Posterior fossa syndrome in children following tumor resection: Knowledge update. In: Surgical neurology international. Vol. 7, Suppl 6 2016, pp. S179 – S183, doi: 10.4103 / 2152-7806.178572 , PMID 27057398 , PMC 4804401 (free full text).