Precancerous disease

from Wikipedia, the free encyclopedia
Classification according to ICD-10
D09.9 Carcinoma in situ, unspecified
ICD-10 online (WHO version 2019)

In medicine, precancerosis is a tissue change that is associated with a statistically increased risk of malignant degeneration. Precancer can be congenital ( e.g. familial adenomatous polyposis ) or acquired ( e.g. actinic keratosis ). According to the statistical probability of the occurrence of cancer, they are divided into facultative precanceroses (later cancer possible) and obligatory precancerous (later cancer significantly likely).

Facultative precancerous disease

Facultative precancerosis is when the risk of degeneration of a malignant tumor is below 30% and a (long) period of more than five years elapses between occurrence and degeneration of the precancerous disease. Examples of an optional precancerous condition are ulcerative colitis , cirrhosis of the liver , and the like. a. The two most common facultative precancerous diseases are actinic keratosis and leukoplakia of the oral cavity and the ear, nose and throat area.

Obligatory precancerous disease

Obligatory precancerous diseases are more likely (> 30%) to turn into a malignant tumor in a short period of less than five years. In the existing disease, an almost 100 percent occurrence of cancer is to be expected. The familial adenomatous polyposis and Gardner's syndrome are obligate precancerous lesions of colon cancer . Xeroderma pigmentosum is a very rare form of an obligatory precancerous condition . Erythroplakia is regarded as an obligatory precancerous condition of the oral mucosa. The dysplastic cell changes in cervical intraepithelial neoplasia grade III and carcinoma in situ (CIS) of the cervix uteri are considered to be an obligatory precancer for cervical carcinoma .

See also

Dysplasia , carcinoma in situ

Web links

Individual evidence

  1. Alphabetical index for the ICD-10-WHO version 2019, volume 3. German Institute for Medical Documentation and Information (DIMDI), Cologne, 2019, p. 716