Red man syndrome
| Classification according to ICD-10 | |
|---|---|
| Y40-Y59 | Unwanted side effects with therapeutic use of drugs, drugs or biologically active substances |
| Y40.8 | Other systemic antibiotics |
| ICD-10 online (WHO version 2019) | |
The Red one syndrome ( Engl. For Red Man Syndrome) describes a medication side effect for the first time in the antibiotic vancomycin was found but also quite with other antibiotics ( ciprofloxacin , rifampin and teicoplanin ) and other drugs (such as the antifungal agent amphotericin B ) can occur.
clinic
Usually the symptoms are limited to itching and burning, the reddened skin (red man) mainly of the face, neck and upper body. Less often there is a drop in blood pressure and swelling of the skin and mucous membranes ( angioedema ). Dizziness, headache, chills and fever as well as abnormal sensations around the mouth are also described. In severe cases, chest pain and shortness of breath are reported. Most patients experience only a slight, fleeting itch at the end of the infusion. This side effect is seen as independent of an anaphylaxis , which is also possible .
The clinical picture develops within 4 to 10 minutes after the start, at the latest shortly after the end of the infusion. There is an association with a rapid infusion rate (<1 hour) of the first dose. In subsequent infusions, the reaction is usually less pronounced; a slow infusion rate (90–120 minutes) can prevent or at least greatly reduce the reaction.
Cause and therapy
Today, the cause is seen to be a release of histamine if the intravenous administration is too rapid. Treatment is based on the degree of reaction with an antihistamine .
See also
literature
- S. Sivagnanam, D. Deleu: Red man syndrome. In: Critical care. Volume 7, Number 2, April 2003, pp. 119-120, ISSN 1364-8535 , doi : 10.1186 / cc1871 , PMID 12720556 . PMC 270616 (free full text).
- M. Nallasivan, F. Maher, K. Murthy: Rare case of "red man" syndrome in a female patient treated with oral vancomycin for Clostridium difficile diarrhea. In: BMJ Case Reports. Volume 2009, 2009, S., ISSN 1757-790X . doi : 10.1136 / bcr.03.2009.1705 . PMID 21886654 . PMC 3029619 (free full text).
