Retina-specific ABC transporter
| Retinal-specific ABC transporter | ||
|---|---|---|
| other names |
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| Properties of human protein | ||
| Identifier | ||
| Gene names | ABCA4 FFM; RMP; ABCR; RP19; STGD; ABC10; ARMD2; CORD3; STGD1 | |
| External IDs | ||
| Orthologue | ||
| human | House mouse | |
| Entrez | 24 | 11304 |
| Ensemble | ENSG00000198691 | ENSMUSG00000028125 |
| UniProt | P78363 | O35600 |
| Refseq (mRNA) | NM_000350 | NM_007378 |
| Refseq (protein) | NP_000341 | NP_031404 |
| Gene locus | Chr 1: 93.99 - 94.12 Mb | Chr 3: 122.04 - 122.18 Mb |
| PubMed search | 24 |
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The retina-specific ABC transporter is a protein that belongs to the protein superfamily of ABC transporters , more precisely to the subfamily of ABC1 transporters. It is the gene ABCA4 encodes on the first chromosome of man is.
family
The ABC transporter superfamily is divided into seven subfamilies: ABC1 , MDR / TAP , MRP , ALD , OABP , GCN20 and Weiß , with the retina-specific ABC transporter belonging to the ABC1 family. This family is the only one whose representatives are found exclusively in multicellular eukaryotes .
function
In Sehzyklus ABCA4 is a zelleinwärts directed retinoid - Flippase : The protein transports all-trans-retinal (ATR) and N-Retinyl phosphatidyl ethanolamines (PE-NR) in the cytoplasm. Once there, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transported to the retinal pigment epithelium, where it is converted into 11-cis retinal .