Sex determining region of Y

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The sex determining region of the Y gene (SRY), just as SRY gene known encodes a transcription factor - the testicular determinative factor ( TDF for English. Testis-determining factor ) - which the (HMG) box protein family DNA binding proteins. The SRY gene, along with other genes, contributes to gender determination in humans and other theria . Most mammals have another gene with a similar function, UBE1 .

SRY is normally on the short arm of the Y chromosome in humans. Accordingly, people who have this chromosome with the corresponding gene usually have a male phenotype . It does not matter how many copies of the X chromosome there are; people with a multiple X chromosome ( Klinefelter syndrome ) also have this. The testis-determining factor protein encoded by the gene controls the further development of the male sex .

In rare cases, the SRY gene on the Y chromosome may be missing or inactivated by mutations, causing people with this defective chromosome to develop into sterile XY women . It is also possible that the gene can be translocated to the X chromosome, which results in sterile male individuals even with an XX set ( XX male ).

It was discovered by Peter N. Goodfellow and the Robin Lovell badge .

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