Sec system
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The Sec system is a protein complex and is used to transport proteins across or into the cytoplasmic membrane in bacteria and higher cells . It occurs in types II, IV, and V of bacterial protein secretion in Gram-negative bacteria . These are transport proteins from the membrane ATPase family .
A distinction is made between cotranslational protein transport and post-translational protein transport . The Sec system can carry out both forms of transport, in contrast to the Tat system , which only transports post-translationally folded proteins. It consists of a chaperone and a multiprotein complex that serves as a translocase . The SecB protein, which acts as a chaperone, binds to the newly synthesized protein and prevents it from folding prematurely . The transport motor SecA recognizes the signal sequence , the protein brings to the Trans Locator from SecY, SecE, SecG SecD and SecF and delivers by ATP - hydrolysis energy for transfer across the membrane.
The transport equation for Sec systems is:
The term Sec system is derived from secretion .
Individual evidence
- ↑ Henderson, IR Type V protein secretion pathway: the autotransporter story (PubmedID: 15590781).
- ^ Arnold JM Driessen, Peter Fekkes, Jeroen PW van der Wolk: The Sec system . In: Current Opinion in Microbiology . tape 1 , no. 2 , April 1, 1998, ISSN 1369-5274 , pp. 216–222 , doi : 10.1016 / S1369-5274 (98) 80014-3 ( sciencedirect.com [accessed March 23, 2020]).
- ↑ TCDB : 3.A.5