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Seiß or Seiss is the family name of the following people:
- Isidor Seiß (1840–1905), German composer and musician
- Reinhard Seiß (* 1970), Austrian urban planner, filmmaker and publicist
- Rudolf Seiß (* 1927), German psychologist
- Rudolf Seiß (actor) , German actor
- Werner Seiss , German pianist, conductor and music teacher
- Willi Seiß (1922–2013), German esotericist and anthroposophist
