Senolytics

Senolytics (derived from the words " senescence " and " lysis ") are molecules that can selectively induce the death ( apoptosis ) of senescent cells .

The goal of those working on the development of senolytics is to use them to delay, prevent, alleviate or reverse age-related diseases. Such positive effects as delaying age-related symptoms and an increased life span have already been proven in animal studies.

Several possible senolytics are currently being investigated. Natural substances known to date with a senolytic effect are, for example, the flavonoids quercetin and fisetin and the alkaloid piperlongumin (from long pepper ). Certain cancer drugs, too, may be able to slow down aging and age-related diseases in low doses. Anticancer drugs can potentially protect against metabolic pathologies regardless of the effects on cancer.

According to initial results, a study with human volunteers also showed a reduction in senescent cells through administration of the cancer drug dasatinib in combination with quercetin.

Individual evidence

1. ↑ BG Childs, M Durik, DJ Baker, JM van Deursen: Cellular senescence in aging and age-related disease: from mechanisms to therapy . In: Nature Medicine , 21, No. 12, 2015, pp. 1424–1435, PMID 26646499 doi: 10.1038 / nm.4000 , PMC 4748967 (free full text)
2. ↑ Kirkland JL, Tchkonia T: Clinical strategies and animal models for developing senolytic agents . In: Experimental Gerontology . 68, 2015, pp. 19-25. doi : 10.1016 / j.exger.2014.10.012 . PMID 25446976 . PMC 4412760 (free full text). Retrieved December 28, 2015.
3. ↑ Kirkland JL et al .: The Clinical Potential of Senolytic Drugs . In: J Am Geriatr Soc. . 65, No. 10, 2017, pp. 2297–2301. doi : 10.1111 / jgs.14969 . PMID 28869295 . PMC 5641223 (free full text).
4. ↑ MJ Yousefzadeh et al .: fisetin is a senotherapeutic did extends health and life span . In: EBioMedicine . 36, 2018, pp. 18–28. doi : 10.1016 / j.ebiom.2018.09.015 . PMID 6197652 . PMC 6197652 (free full text).
5. ↑ Kim Baumann: Rejuvenating senolytics . In: Nature Reviews Molecular Cell Biology . 19, No. 9, July 27, 2018, ISSN  1471-0072 , pp. 543-543. doi : 10.1038 / s41580-018-0047-5 .
6. ^ Li W et al .: Emerging senolytic agents derived from natural products . In: Mech Aging Dev. . 181, 2019, pp. 1-6. doi : 10.1016 / j.mad.2019.05.001 . PMID 31077707 .
7. ↑ MV Blagosklonny: Selective anti-cancer agents as anti-aging drugs . In: Cancer Biology & Therapy . 14, No. 12, 2013, pp. 1092–7. doi : 10.4161 / cbt.27350 . PMID 24345884 . PMC 3912031 (free full text). Retrieved December 27, 2015.
8. ↑ C Slack, N Alic, L Partridge: Could cancer drugs provide ammunition against aging? . In: Cell Cycle (Georgetown, Tex.) . 2015. doi : 10.1080 / 15384101.2015.1118905 . PMID 26587873 . PMC 4825846 (free full text). Retrieved December 27, 2015.
9. ↑ LJ Hickson et al. LGPL Prata et al .: Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease . In: J Am Geriatr Soc. . 47, 2019, pp. 446-456. doi : 10.1016 / j.ebiom.2019.08.069 . PMID 31542391 . PMC 6796530 (free full text).

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