Signal Transducer CD24
| Signal transducer CD24 | ||
|---|---|---|
| other names |
Small cell lung carcinoma cluster 4 antigen, heat stable antigen CD24, HSA, CD24A |
|
| Properties of human protein | ||
| Mass / length primary structure | 80 amino acids , 8,097 Da | |
| Identifier | ||
| External IDs | ||
Signal transducer CD24 is a surface protein in B cells , T cells and granulocytes .
properties
CD24 is a cell adhesion molecule and promotes the activation of the B cell receptor in B cells when antigen binds . CD24 has a GPI anchor and is sialylated . CD24 groups the B cell receptors in lipid rafts . It is also involved in the activation of granulocytes. In T cells it is a costimulator .
CD24 occurs more frequently in some tumors and is therefore a marker . It is believed to be oncogenic . A lack of the function of the CD24 is involved in the development of autoimmune diseases .
Web links
Individual evidence
- ↑ MR Hough, PM Rosten, TL Sexton, R. Kay, RK Humphries: Mapping of CD24 and homologous sequences to multiple chromosomal loci. In: Genomics. Volume 22, Number 1, July 1994, pp. 154-161, doi : 10.1006 / geno.1994.1356 , PMID 7959762 .
- ^ A b Y. Tan, M. Zhao, B. Xiang, C. Chang, Q. Lu: CD24: from a Hematopoietic Differentiation Antigen to a Genetic Risk Factor for Multiple Autoimmune Diseases. In: Clinical reviews in allergy & immunology. Volume 50, Number 1, February 2016, pp. 70-83, doi : 10.1007 / s12016-015-8470-2 , PMID 25666875 .
- ↑ A. Jaggupilli, E. Elkord: Significance of CD44 and CD24 as cancer stem cell markers: an enduring ambiguity. In: Clinical & developmental immunology. Volume 2012, 2012, p. 708036, doi : 10.1155 / 2012/708036 , PMID 22693526 , PMC 3369436 (free full text).
- ↑ X. Fang, P. Zheng, J. Tang, Y. Liu: CD24: from A to Z. In: Cellular & molecular immunology. Volume 7, number 2, March 2010, pp. 100-103, doi : 10.1038 / cmi.2009.119 , PMID 20154703 , PMC 4001892 (free full text).