Split vaccine

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Split vaccines , also called (inactivated) partial particle vaccines or split vaccines , are a type of vaccine formulation in which the virions are broken up with organic solvents or surfactants .

properties

In the course of virus cleavage, enveloped viruses form larger fragments of the virus envelope , which are further cleaned before they are administered as a vaccine . You offer fragments of the pathogen to the immune system and train an immune response without infection with the virus, which results in fewer unwanted vaccination reactions. Split vaccines belong to the category of dead vaccines because the administered material is no longer infectious or capable of multiplying. Because of the low uptake in cells compared to attenuated viruses, DNA vaccines of viral genes or viral vectors , the cellular immune response is usually not activated in the case of split vaccines.

literature

  • Joseph D. Bronzino: Biomedical Engineering Handbook 2 , Volume 2 of The electrical engineering handbook series , Issue 2, Springer Science & Business Media, 2000. ISBN 9783540668084 . Pp. 105-9.

Individual evidence

  1. ^ PR Dormitzer, TF Tsai, G. Del Giudice: New technologies for influenza vaccines. In: Human vaccines & immunotherapeutics. Volume 8, number 1, January 2012, pp. 45-58, doi : 10.4161 / hv.8.1.18859 , PMID 22251994 .
  2. ^ H. Wagner, A. Heit, F. Schmitz, S. Bauer: Targeting split vaccines to the endosome improves vaccination. In: Current Opinion in Biotechnology. Volume 15, Number 6, December 2004, pp. 538-542, doi : 10.1016 / j.copbio.2004.09.006 , PMID 15560980 .