Cellular immune response

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The cellular immune response describes the part of the adaptive immune response that is mediated by cytotoxic T cells .

After a contact with an intracellular antigen can all cell nucleus -containing cells this antigen in short peptides of eight to eleven amino acids decompose and at its major histocompatibility complex present type 1 (MHC1). This complex is bound to Killer T cells (more precisely: cytotoxic T cells ) by CD8 and the T cell receptor . If another signal is added, e.g. B. by a costimulator or cytokines ( esp . Interferon-γ and interleukin-2 ), the cytotoxic T-cell releases perforin , which perforates the cell membrane of the bound, presenting cell. Granzyme B is also secreted , which digests the bound cell as a protease .

The cellular immune response is also enhanced by phagocytes , natural killer cells and T- type 1 helper cells and B lymphocytes .

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