Pointed hairline
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A pointed hairline ( engl. Widow's peak , literally translated as "widow tip") is a descending V-shaped area in the center of the hairline of the forehead above.
The characteristic of the pointed hairline is inherited as an autosomal - dominant trait. The allele "pointed hairline" dominates the allele "straight hairline".
The English name Widow's peak is probably based on the shape of a cap (biquoquet) worn by widows in the 16th century . In the English-speaking world, this term is used for both genders.
Syndromes associated with a pointy hairline
While in most cases a pointed hairline is a completely normal genetic trait such as red hair or attached earlobes , some very rare hereditary diseases are associated with the "pointed hairline" phenotype . So there is an obvious relationship between hypertelorism (large eye relief) and a pointed hairline.
In the following syndromes, which are also associated with hypertelorism , the "pointed hairline" phenotype is often developed:
- The Aarskog Scott syndrome ( X-linked - recessive , sometimes autosomal recessive)
- The cranio-fronto-nasal dysplasia (CFNS), (X-linked dominant genetic locus Xq12)
- The fronto-nasal dysplasia (sporadic mutations)
- The Waardenburg syndrome (WS 1) (autosomal dominant gene locus 2q35)
- The recessive form of the facio-genito-digital syndrome (mostly X-linked)
- The Opitz BBB / G syndrome (autosomal dominant and X-linked recessive)
- The Widow's-peak syndrome (X-linked dominant)
literature
- IN Tiwari and RK Sandhir: Widow's peak anomaly with alopecia. In: Plastic and Reconstructive Surgery 80, 1987, pp. 473-474. PMID 3628586
Web links
- Understanding Genetics (Engl.)
Individual evidence
- ↑ Roxanne Roberts, Amy Argetsinger: Paul Ryan's widow's peak: A game-changer in GOP veepstakes? In: Washington Post. April 6, 2012, accessed February 18, 2020 .
- ↑ www.websters-online-dictionary.org ( page no longer available , search in web archives ) Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice. accessed on October 2, 2008
- ↑ AM Winchester: Genetics. Houghton Mifflin Co., 2nd Edition, 1958, p. 359.
- ↑ M. Livingston: Crash Course Genetics. In: Neue Zürcher Zeitung 09, 2000.
- ↑ J. Jadassohn et al.: Handbook of skin and sexually transmitted diseases. German Dermatological Society, Springer, 1933.
- ↑ D. Lennox: Now You Know. Dundurn Press Ltd., 2003, ISBN 1-55002-648-8 , p. 112.
- ↑ Wordsmith.Org: widow's peak
- ↑ Pointed hairline. In: Online Mendelian Inheritance in Man . (English).
- ^ DW Smith, MM Cohen: Widow's peak scalp-hair anomaly and its relation to ocular hypertelorism. In: The Lancet 2, 1973, pp. 1127-1128. PMID 4128017
- ^ P. Berman et al .: The inheritance of the Aarskog facial-digital-genital syndrome. In: J. Pediat. 86, 1974, pp. 885-891. PMID 1127528
- ↑ FACIOGENITAL DYSPLASIA. In: Online Mendelian Inheritance in Man . (English).
- ↑ Orpha.net: Aarskog-Scott Syndrome
- ↑ CRANIOFRONTONASAL SYNDROME; CFNS. In: Online Mendelian Inheritance in Man . (English).
- ↑ Orpha.net: dysplasia, cranio-fronto-nasal
- ↑ Orpha.net: dysplasia fronto
- ↑ FRONTONASAL DYSPLASIA. In: Online Mendelian Inheritance in Man . (English).
- ↑ WAARDENBURG SYNDROME, TYPE I; WS1. In: Online Mendelian Inheritance in Man . (English).
- ↑ Orpha.net: Waardenburg syndrome type 1
- ↑ FACIODIGITOGENITAL SYNDROME, RECESSIVE. In: Online Mendelian Inheritance in Man . (English).
- ↑ Orpha.net: Fazio-genito-digital syndrome, recessive form
- ↑ HYPERTELORISM WITH ESOPHAGEAL ABNORMALITY AND HYPOSPADIAS. In: Online Mendelian Inheritance in Man . (English).
- ↑ WIDOW'S PEAK SYNDROME. In: Online Mendelian Inheritance in Man . (English).
- ↑ BJ LaDine et al .: Syndrome of short stature, widow's peak, ptosis, posteriorly angulated ears, and joint problems: exclusion of the Aarskog (FGD1) gene as a candidate gene. In: Am. J. Med. Genet. 99, 2001, pp. 248-251. PMID 11241498