Stauffer Syndrome

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The Stauffer syndrome is a non-metastasis-related dysfunction of the liver in patients suffering from a renal cell carcinoma are ill. It was first described by Stauffer in 1961. This paraneoplastic syndrome manifests itself in 3 to 20% of cases as an increase in alkaline phosphatase , in 67% to prolong the thromboplastin time and hypoalbuminemia and in 20 to 30% of cases to increase indirect bilirubin and alpha2- and γ- Globulins . Fever, weight loss and fatigue are also included. Of course, liver metastases must be excluded. There is increased retention in the bromosulphthalein test.

Histologically, the Stauffer syndrome results in nonspecific hepatitis with lymphocytic infiltrate and necrosis zones. There is an increased production of enzymes in the liver. Surgical removal of the primary tumor, in this case a partial kidney resection or nephrectomy, can also treat Stauffer's syndrome in 60 to 70% of cases. Persistence or recurrence of Stauffer syndrome is associated with a poor prognosis for the underlying disease or with a recurrent tumor .

Stauffer syndrome occurs almost exclusively in patients who have the primary tumor in the right kidney.

An increased production of interleukin-6 and prostaglandins triggered by the tumor is very likely responsible for the symptoms. The release of these messenger substances causes calcium ions to be released by osteoclasts .

Individual evidence

  1. ^ M. Steins, J. van de Loo: Pathogenesis of nephropathic coagulopathies. In: Onkodin.de. dated October 22, 2002.
  2. ↑ a b c J. Bedke et al.: Paraneoplastic syndromes of renal cell carcinoma. In: Der Urologe A. 46, 2007, pp. 45–48. doi: 10.1007 / s00120-006-1269-2
  3. ↑ G. Giannakos et al: Stauffer's syndrome variant associated with renal cell carcinoma. In: Int J Urol. 12, 2005, pp. 757-759. PMID 16174051
  4. ↑ GR Mundy: Pathophysiology of cancer-associated hypercalcemia. In: Semin Oncol . 17, 1990, pp. 10-15. PMID 2185548

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