Stuart A. Lipton

Stuart Arthur Lipton (born January 11, 1950 in Danbury (Connecticut) ) is an American neuroscientist.

Lipton graduated from Cornell University with a bachelor's degree in 1971 and the University of Pennsylvania with an MD in medicine in 1977 and a Ph. D. in biophysics and biochemistry that same year. This was followed by specialist training as a neurologist (residency) at various Boston hospitals ( Massachusetts General Hospital , Brigham and Woman's Hospital, Beth Israel Hospital, Children's Hospital ). He then conducted research in Torsten Wiesel's laboratory at Harvard Medical School (1980 to 1983) and was an assistant professor at the Beth Israel Hospital in Boston.

From 1987 to 1997 he was director of the Laboratory for Cellular and Molecular Neuroscience at Children's Hospital Boston and at the same time Associate Professor at Harvard Medical School and neurologist at Brigham and Woman's Hospital Boston.

From 1999 he was Professor and Director of the Sanford-Burnham Medical Research Institute (formerly Burnham Institute) in La Jolla . He is also an Adjunct Professor at the University of California, San Diego , the Scripps Research Institute and the Salk Institute for Biological Studies .

In his laboratory, he studies the molecular mechanisms of neurodegenerative diseases and the neural effects of strokes and AIDS.

Together with colleagues, he succeeded in discovering (1993) and cloning the transcription factor MEF2C, which causes the differentiation of stem cells into nerve cells in embryogenesis.

His group developed the first drug that acts as an antagonist to the glutamate receptor ( memantine ). It has been approved as an Alzheimer's drug.

Together with colleagues, he discovered the mechanism of S-nitrolysis , in which proteins are modified by nitric oxide.

In 2004 he received the Ernst Jung Prize .

Web links

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Individual evidence

1. ↑ Life data according to American Men and Women of Science , Thomson Gale 2004