Denny-Brown Syndrome

Classification according to ICD-10
G63.1 *	Polyneuropathy in neoplasms
C34 +	Malignant new growth of the bronchi and lungs
ICD-10 online (WHO version 2019)

The Denny-Brown syndrome (Subacute sensory neuropathy, ganglionitis) is one of the paraneoplastic polyneuropathy , d. H. a disease of the peripheral nerves on the base of a malignant tumor , here mostly a so-called small cell lung carcinoma .

In Denny-Brown syndrome, the sensory fibers are primarily affected, with degeneration of the spinal and autonomic ganglia . This results in progressive , distally accentuated painful paresthesia over weeks and months , in the further course disturbances of the deep sensitivity with pronounced sensitive ataxia and pseudo- athetosis and disturbances of the autonomic regulation. Anti-Hu antibodies can be positive, more rarely CV ₂ / CRMP ₅ , amphiphysine and ANNA-3 antibodies.

literature

• Masuhr and Neumann: Neurology . Stuttgart 2005, ISBN 3-13-135945-5

Individual evidence

1. ↑ Guideline "Diagnostics in Polyneuropathies" http://www.dgn.org/leitlinien/2331-ll-44-2012-diagnostik-bei-polyneuropathien .

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !