Susceptibility gene

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Susceptibility genes are genes that have a hereditary increased likelihood of disease .

properties

In the case of gene variants in DNA repair genes, susceptibility to genetic damage can increase the likelihood of tumors developing . There are a number of gene products and enzymes that are constantly busy finding and repairing defects in DNA . If these genes are missing or if they are inactivated by mutation or deletions, there is an accumulation of DNA errors, which can then also affect the proto-oncogenes and tumor suppressor genes . They are used for quality control of the DNA and are therefore a risk factor for mutation and chromosome defects .

Individual evidence

  1. ↑ Y. Yang, Y. Xie, L. Xian: Breast cancer susceptibility gene 1 (BRCA1) predict clinical outcome in platinum- and toxal-based chemotherapy in non-small-cell lung cancer (NSCLC) patients: a system review and meta -analysis. In: Journal of Experimental & Clinical Cancer Research . Volume 32, 2013, p. 15, ISSN  1756-9966 . doi : 10.1186 / 1756-9966-32-15 . PMID 23497550 . PMC 3610101 (free full text).
  2. ^ AP Mullin, A. Gokhale, J. Larimore, V. Faundez: Cell biology of the BLOC-1 complex subunit dysbindin, a schizophrenia susceptibility gene. In: Molecular neurobiology. Volume 44, Number 1, August 2011, pp. 53-64, ISSN  1559-1182 . doi : 10.1007 / s12035-011-8183-3 . PMID 21520000 . PMC 3321231 (free full text).
  3. ↑ R. Asleh, AP Levy: In vivo and in vitro studies Establishing haptoglobin as a major susceptibility gene for diabetic vascular disease. In: Vascular health and risk management. Volume 1, Number 1, 2005, pp. 19-28, ISSN  1176-6344 . PMID 17319095 . PMC 1993923 (free full text).
  4. ↑ K. Somyajit, S. Subramanya, G. Nagaraju: RAD51C: a novel cancer susceptibility gene is linked to Fanconi anemia and breast cancer. In: Carcinogenesis . Volume 31, Number 12, December 2010, pp. 2031-2038, ISSN  1460-2180 . doi : 10.1093 / carcin / bgq210 . PMID 20952512 . PMC 2994284 (free full text).
  5. ↑ PJ O'Donovan, DM Livingston: BRCA1 and BRCA2: breast / ovarian cancer susceptibility gene products and participants in DNA double-strand break repair. In: Carcinogenesis. Volume 31, Number 6, June 2010, pp. 961-967, ISSN  1460-2180 . doi : 10.1093 / carcin / bgq069 . PMID 20400477 .