Syntaxine
Syntaxine | ||
---|---|---|
Transporter classification | ||
TCDB | 1.F.1 | |
designation | SVF pore |
Syntaxins are proteins that integrate into membranes and participate in the fusion of membranes. One example is the SNARE proteins that play a role in vesicle fusion . Syntaxin 1 (t-SNARE) interacts with SNAP-25 and Synaptobrevin 2 (v-SNARE) to form the so-called SNARE complex. As a result, the vesicle membrane and the cell membrane are brought very close to one another, which simplifies the fusion of the two membranes. Syntaxin 3 is the only syntaxin that has an enzymatic interface. This separates the helical intracellular part of the syntaxin 3 from the transmembrane part. In the non-cleaved state, the helical part has a low affinity for RanBP5, while the helical cleavage product has a high affinity. This complex can migrate into the cell nucleus and exert a gene-regulating function there. This could possibly play an important role in the cell polarity , especially since syntaxin 3 itself is involved in cell polarization.
literature
- I. Fernandez, J. Ubach, I. Dulubova, X. Zhang, TC Südhof, J. Rizo: Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A. In: Cell. 94 (6), September 1998, pp. 841-849. doi: 10.1016 / S0092-8674 (00) 81742-0 . PMID 9753330 .
- MK Bennett, JE García-Arrarás, LA Elferink, K. Peterson, AM Fleming, CD Hazuka, RH Scheller: The syntaxin family of vesicular transport receptors. In: Cell. 74 (5), September 1993, pp. 863-873. doi: 10.1016 / 0092-8674 (93) 90466-4 . PMID 7690687 .
- Danko D Georgiev, James F Glazebrook: Subneuronal processing of information by solitary waves and stochastic processes. In: Sergey Edward Lyshevski: Nano and Molecular Electronics Handbook. Nano and Microengineering Series. CRC Press, 2007, ISBN 978-0-8493-8528-5 , pp. 17-1 to 17-41.
- DJ Woodbury, K. Rognlien: The t-SNARE syntaxin is sufficient for spontaneous fusion of synaptic vesicles to planar membranes. In: Cell Biol. Int. 24 (11), 2000, pp. 809-818. doi: 10.1006 / cbir.2000.0631 . PMID 11067766 .
- X. Han, CT Wang, J. Bai, ER Chapman, MB Jackson: Transmembrane segments of syntaxin line the fusion pore of Ca2 + -triggered exocytosis. In: Science. 304 (5668), V, pp. 289-292. doi: 10.1126 / science.1095801 . PMID 15016962 .
- S. Pereira, A. Massacrier, P. Roll, A. Vérine, MC Etienne-Grimaldi, Y. Poitelon, A. Robaglia-Schlupp, S. Jamali, N. Roeckel-Trevisiol, B. Royer, P. Pontarotti, C. Lévêque, M. Seagar, N. Lévy, P. Cau, P. Szepetowski: Nuclear localization of a novel human syntaxin 1B isoform. In: Genes. 423 (2), November 2008, pp. 160-171. doi: 10.1016 / j.gene.2008.07.010 . PMID 18691641 .
Web links
- PROSITE : Syntaxin / Epimorphin protein family (English)
- PROSITE : t-SNARE proteins with a terminal roll (English)