Syntaxine

from Wikipedia, the free encyclopedia
Syntaxine
Transporter classification
TCDB 1.F.1
designation SVF pore

Syntaxins are proteins that integrate into membranes and participate in the fusion of membranes. One example is the SNARE proteins that play a role in vesicle fusion . Syntaxin 1 (t-SNARE) interacts with SNAP-25 and Synaptobrevin 2 (v-SNARE) to form the so-called SNARE complex. As a result, the vesicle membrane and the cell membrane are brought very close to one another, which simplifies the fusion of the two membranes. Syntaxin 3 is the only syntaxin that has an enzymatic interface. This separates the helical intracellular part of the syntaxin 3 from the transmembrane part. In the non-cleaved state, the helical part has a low affinity for RanBP5, while the helical cleavage product has a high affinity. This complex can migrate into the cell nucleus and exert a gene-regulating function there. This could possibly play an important role in the cell polarity , especially since syntaxin 3 itself is involved in cell polarization.

literature

  • I. Fernandez, J. Ubach, I. Dulubova, X. Zhang, TC Südhof, J. Rizo: Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A. In: Cell. 94 (6), September 1998, pp. 841-849. doi: 10.1016 / S0092-8674 (00) 81742-0 . PMID 9753330 .
  • MK Bennett, JE García-Arrarás, LA Elferink, K. Peterson, AM Fleming, CD Hazuka, RH Scheller: The syntaxin family of vesicular transport receptors. In: Cell. 74 (5), September 1993, pp. 863-873. doi: 10.1016 / 0092-8674 (93) 90466-4 . PMID 7690687 .
  • Danko D Georgiev, James F Glazebrook: Subneuronal processing of information by solitary waves and stochastic processes. In: Sergey Edward Lyshevski: Nano and Molecular Electronics Handbook. Nano and Microengineering Series. CRC Press, 2007, ISBN 978-0-8493-8528-5 , pp. 17-1 to 17-41.
  • DJ Woodbury, K. Rognlien: The t-SNARE syntaxin is sufficient for spontaneous fusion of synaptic vesicles to planar membranes. In: Cell Biol. Int. 24 (11), 2000, pp. 809-818. doi: 10.1006 / cbir.2000.0631 . PMID 11067766 .
  • X. Han, CT Wang, J. Bai, ER Chapman, MB Jackson: Transmembrane segments of syntaxin line the fusion pore of Ca2 + -triggered exocytosis. In: Science. 304 (5668), V, pp. 289-292. doi: 10.1126 / science.1095801 . PMID 15016962 .
  • S. Pereira, A. Massacrier, P. Roll, A. Vérine, MC Etienne-Grimaldi, Y. Poitelon, A. Robaglia-Schlupp, S. Jamali, N. Roeckel-Trevisiol, B. Royer, P. Pontarotti, C. Lévêque, M. Seagar, N. Lévy, P. Cau, P. Szepetowski: Nuclear localization of a novel human syntaxin 1B isoform. In: Genes. 423 (2), November 2008, pp. 160-171. doi: 10.1016 / j.gene.2008.07.010 . PMID 18691641 .

Web links