Systolic heart failure

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Pressure-volume curve

The systolic heart failure or isolated systolic dysfunction is defined by a decrease in left ventricular function (LVEF <50%) at elevated left ventricular end-diastolic pressure-volume and (LVEDP and LVEDV). The stroke volume can be maintained by increasing the LVEDP and LVEDV ( Frank-Starling mechanism ). The left ventricular end-systolic volume (LVESV) is also increased with an unchanged heart rate.

The isolated systolic dysfunction is caused by impaired left ventricular contractility ( heart attack ) or increased afterload .

The isolated systolic dysfunction causes a shift in the pressure-volume curve to the right, secondary to the reduced ventricular contractility. The width of the pressure-volume curve decreases as a result of the reduced stroke volume.

The heart compensates for the reduced LVEF and the increased preload via left ventricular hypertrophy and ventricular dilation ( Frank-Starling mechanism ). The result is an increased myocardial work performance and a further decrease in the systolic pump function.

See also

Individual evidence

  1. ↑ Jessup M, Brozena S. Heart failure. N Engl J Med 2003; 348: 2007.
  2. ↑ McMurray JJ, Adamopoulos S, Anker SD, et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J 2012; 33: 1787.
  3. ↑ Guideline for the management of heart failure caused by systolic dysfunction: Part I. Guideline development, etiology and diagnosis. Chavey WE 2nd et al. At the Fam Physician. 2001 Sep 1; 64 (5): 769-74.
  4. ↑ Guideline for the management of heart failure caused by systolic dysfunction: Part II. Treatment. Chavey WE 2nd et al. At the Fam Physician. 2001 Sep 15; 64 (6): 1045-54.
  5. ^ Koelling ™, Aaronson KD, Cody RJ, et al. Prognostic significance of mitral regurgitation and tricuspid regurgitation in patients with left ventricular systolic dysfunction. On Heart J 2002; 144: 524.
  6. ↑ Heart Failure Society of America (HFSA) practice guidelines. HFSA guidelines for management of patients with heart failure caused by left ventricular systolic dysfunction-pharmacologic approaches. J Card Fail. 1999; 5: 357-82.