Thomas Hoye

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Thomas Robert Hoye (born June 19, 1950 in New Castle , Pennsylvania ) is an American chemist ( organic chemistry ). He is a professor at the University of Minnesota .

Hoye graduated from Bucknell University with bachelor's and master's degree in 1972 and in 1976 at the Harvard University in Robert B. Woodward with the work Total synthesis of illudinine, illudalic acid, and illudacetalic acid doctorate . In 1976 he became Assistant Professor and in 1988 Professor at the University of Minnesota. There he is Merck Professor of Chemistry.

He deals with the total synthesis of natural products and the development of the necessary synthesis methods (including the synthetic application of Fischer carbenes ). He also deals with structure determination of natural products and NMR analysis and methodology (such as No D NMR, No Deuterium Proton NMR), stereochemistry and symmetry, drug delivery with nano-particles, sustainable polymers ( polyurethanes made from biological lactones ) and polymer synthesis and with peptides.

Among other things, his group recently succeeded in the total synthesis of okilatomycin, peloruside A, leuconolam, callipeltoside A and in 2005 the elucidation of the main pheromone of the migration of sea lamprey (Petromyzonamine disulfate, PADS)

In 2012 he and his group introduced the hexadehydro- Diels-Alder reaction (HDDA), the aromatic ene reaction, and they introduced hydrocarbon desaturation by aryne (Benzyne).

In 2016 he received the Robert Robinson Award . From 1985 to 1989 he was a Sloan Research Fellow .

Web links

Individual evidence

  1. Life and career data according to American Men and Women of Science , Thomson Gale 2004
  2. ^ Biographical data, publications and academic family tree of Thomas Robert Hoye at academictree.org, accessed on February 12, 2018.