Transcortin
| Transcortin | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 383 amino acids | |
| Identifier | ||
| Gene name | SERPINA6 | |
| External IDs | ||
| Inhibitor classification | ||
| MEROPS | I04.954 | |
| Occurrence | ||
| Parent taxon | Mammals | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 866 | 12401 |
| Ensemble | ENSG00000170099 | ENSMUSG00000060807 |
| UniProt | P08185 | Q06770 |
| Refseq (mRNA) | NM_001756 | NM_007618 |
| Refseq (protein) | NP_001747 | NP_031644 |
| Gene locus | Chr 14: 94.3 - 94.32 Mb | Chr 12: 103.65 - 103.66 Mb |
| PubMed search | 866 |
12401
|
Transcortin , ( CBG , from English: Corticosteroid binding globulin ) is a plasma protein in mammals , whose job is to bind and transport glucocorticoids and progesterone in the blood. It belongs to the group of α₁-globulins . Production takes place in the liver and is regulated by estrogen .
Transcortin has a high affinity for cortisol , which is believed to be biologically active only in its non-transcortin-bound form. About 75% of the cortisol in the circulation is bound to transcortin.
The molecular mass of transcortin is 52,000 Daltons , the normal concentration in the serum is about 37 mg / l, but can double during pregnancy or after taking ovulation inhibitors . With cirrhosis of the liver , the concentration is reduced.
literature
- A. Zhou, Z. Wei, PL Stanley, RJ Read, PE Stein, RW Carrell: The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release. In: J. Mol. Biol. 380 (1), June 2008, pp. 244-251. doi: 10.1016 / j.jmb.2008.05.012 . PMID 18513745 .
- GL Hammond, CL Smith, IS Goping, DA Underhill, MJ Harley, J. Reventos, NA Musto, GL Gunsalus, CW Bardin: Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors. In: Proc Natl Acad Sci U.S.A. 84 (15), Aug 1987, pp. 5153-5157. doi: 10.1073 / pnas.84.15.5153 . PMC 298812 (free full text). PMID 3299377 .
- BC Byth, GD Billingsley, DW Cox: Physical and genetic mapping of the serpin gene cluster at 14q32.1: allelic association and a unique haplotype associated with alpha 1-antitrypsin deficiency. In: Am J Hum Genet. 55 (1), Jul 1994, pp. 126-133. PMC 1918218 (free full text). PMID 7912884 .
- E. Edward Bittar, Neville Bittar: Molecular and Cellular Endocrinology. Elsevier, 1997, ISBN 1-55938-815-3 , p. 238.
- Principles and Practice of Endocrinology and Metabolism. Lippincott Williams & Wilkins, 2001, ISBN 0-7817-1750-7 , p. 712.
- Negi: Introduction To Endocrinology. PHI Learning Pvt., 2009, ISBN 978-81-203-3850-0 , p. 268.
- JF Dunn, BC Nisula, D. Rodbard: Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma. In: The Journal of Clinical Endocrinology and Metabolism. 53 (1), July 1981, pp. 58-68. doi: 10.1210 / jcem-53-1-58 . PMID 7195404 .
- BU Musa, US Seal, RP Doe: Elevation of certain plasma proteins in man following estrogen administration: a dose-response relationship. In: J. Clin. Endocrinol. Metab. 25 (9), September 1965, pp. 1163-1166. doi: 10.1210 / jcem-25-9-1163 . PMID 4284083 .
- DJ Torpy, BA Lundgren, JT Ho, JG Lewis, HS Scott, V. Mericq: CBG Santiago: a novel CBG mutation. In: J. Clin. Endocrinol. Metab. 97 (1), January 2012, pp. E151-E155. doi: 10.1210 / jc.2011-2022 . PMID 22013108 .
- MI Rosen, SM Shnider, G. Levinson, SC Hughes: Shnider and Levinson's anesthesia for obstetrics. Lippincott Williams & Wilkins, Hagerstwon, MD 2002, ISBN 0-683-30665-0 , p. 13.