Transcription factor IIE
Transcription factor IIE (TFIIE) is a protein complex in the nucleus of bilateral animals (bilateria), which is part of the pre-initiation complex for the transcription of all genes . In particular, TFIIE mediates the binding of TFIIH to the polymerase- TFIIF - TFIID - TFIIA - TFIIB promoter complex. TFIIE and TFIIH are important so that the promoter bound by the complex (part of the DNA) can be released after the first phosphodiester bond of the mRNA has been closed.
TFIIE is a tetramer of two subunits (α, β) with 439 and 291 amino acids. TFIIE-β is already found in simple multicellular animals and fungi and contains a DNA-binding domain, while TFIIE-α has a zinc finger motif. TFIIE-α continues to interact with TAF6 and TFIIE-β with FACT .
Individual evidence
- ↑ Reinberg / reactome: Binding of TFIIE to the growing preinitiation complex ( page no longer available , search in web archives ) Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice.
- ↑ a b UniProt P29083 , UniProt P29084
- ↑ Timmers / reactome: RNA Polymerase II Promoter Escape ( page no longer available , search in web archives ) Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice.
