Transposase
| Transposase | ||
|---|---|---|
|
||
| Enzyme classification | ||
| EC, category | 2.7.7. , Nucleotidyl transferase | |
| Substrate | DNA with gene | |
| Products | DNA with a gene in a different position | |
A transposase is an enzyme that can cut out its own coding DNA sequence with surrounding areas via the endonuclease function (conservative transposition) or copy it via replication (replicative transposition) and then reintegrate it into another DNA area. Transposases bind to matching single-stranded DNA, which must be surrounded by two opposing, more or less identical sequences ( inverted repeats ).
Since the transposase thus transfers nucleotides, it is counted among the nucleotidyl transferases ( EC number 2.7.7).
DNA areas that code for a transposase and are flanked by inverted repeats (in some cases they can also contain other genes ) are known as DNA transposons .
Web links
- Jennifer McDowall / Interpro: Protein Of The Month: Transposase. On: ebi.ac.uk ( Memento from July 28, 2009 in the Internet Archive )