Viscotoxins

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The viscotoxin denotes a group of toxins from the Weißbeerigen mistletoe ( Viscum album ).

properties

Viscotoxins are small, cysteine- rich, cationic peptides of about 5 kDa from the group of thionins . In addition to mistletoe lectins, they are the cause of the toxic effect . They are cytotoxic to cells from various kingdoms such as animals , fungi and bacteria . Viscotoxin A3 is presumably a pore-forming toxin . Viscotoxins are found in the leaves and stems of European mistletoe.

Viscotoxins are a component of mistletoe extracts that are used in chemotherapy .

Individual evidence

  1. ↑ a b c M. Giudici, JA Poveda, ML Molina, L. de la Canal, JM González-Ros, K. Pfüller, U. Pfüller, J. Villalaín: Antifungal effects and mechanism of action of viscotoxin A3. In: FEBS Journal . Volume 273, Number 1, January 2006, pp. 72-83, doi : 10.1111 / j.1742-4658.2005.05042.x , PMID 16367749 .
  2. ↑ G. Schaller, K. Urech, G. Grazi, M. Giannattasio: Viscotoxin composition of the three European subspecies of Viscum album. In: Planta Medica . Volume 64, Number 7, October 1998, pp. 677-678, doi : 10.1055 / s-2006-957553 , PMID 17253311 .
  3. ↑ A. Büssing, K. Suzart, K. Schweizer: Differences in the apoptosis-inducing properties of Viscum album L. extracts. In: Anti-Cancer Drugs . Volume 8 Suppl 1, April 1997, pp. S9-14, PMID 9179360 .