WASP / WAVE proteins
The WASP / WAVE proteins , also called Wiskott-Aldrich syndrome proteins , or just the WASP proteins, represent a family of proteins whose members play a special role in the regulation of actin nucleation , especially that of the Arp 2/3 complex play.
Structure and function
WASP / WAVE proteins have five members: the Wiskott-Aldrich syndrome protein (WASP), N-WASP , WAVE1 / SCAR1 , WAVE2, and WAVE3 . They all have structural and biochemical properties in common - especially the C -terminal VCA domain , which is used to recruit and activate the Arp 2/3 complex, is highly conserved. The activation of the WASP / WAVE proteins in turn by biochemical signals differ from one another. This is especially true for the strongly conserved N -terminal areas. The N-terminal WH1 (WASP homology 1) domains of WASP and N-WASP have structural similarities with EVH1 domains, which are known from the Ena / VASP protein family, and the WH1 domains bind to proline- containing ones Motifs. In contrast, the WHD (WAVE homology) domains of the WAVE proteins interact with Abi proteins.
Individual evidence
- ↑ a b actin dynamics and WASP / WAVE proteins (PDF). biospektrum.de. Retrieved August 7, 2016.
- ↑ S. Kurisu, T. Takenawa: The WASP and WAVE family proteins. In: Genome biology. Volume 10, number 6, 2009, p. 226, doi : 10.1186 / gb-2009-10-6-226 , PMID 19589182 , PMC 2718491 (free full text) (review).