Cell-free fetal DNA

Cell-free fetal DNA ( Cell-free fetal DNA , cffDNA , cfDNA ) is fetal DNA , which is free in the maternal bloodstream is circulated. In some countries it is examined as part of an initial screening during pregnancy diagnosis.

properties

The fetal DNA can be taken from the mother by a simple venipuncture from the 9th week of pregnancy , it is therefore a non-invasive and therefore harmless alternative to the amniotic fluid test . Many of the prenatal paternity tests available on the market are based on this method, which compares the genetic markers ( SNP ) of the adopted father and the embryo . The blood of the mother and the adopted father are sent abroad for this purpose, as any prenatal paternity tests are prohibited in Germany .

Individual evidence

1. ↑ M. Allyse, MA Minear, E. Berson, S. Sridhar, M. Red, A. Hung, S. Chandrasekharan: Non-invasive prenatal testing: a review of international implementation and challenges. In: International journal of women's health. Volume 7, 2015, ISSN  1179-1411 , pp. 113–126, doi : 10.2147 / IJWH.S67124 , PMID 25653560 , PMC 4303457 (free full text).
2. ^ AI Wong, YM Lo: Noninvasive fetal genomic, methylomic, and transcriptomic analyzes using maternal plasma and clinical implications. In: Trends in Molecular Medicine . Volume 21, number 2, February 2015, ISSN  1471-499X , pp. 98-108, doi : 10.1016 / j.molmed.2014.12.006 , PMID 25618775 .