Somatomedin: Difference between revisions
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{{Short description|Group of proteins responsible for both promotion and inhibition of cellular growth}} |
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'''Somatomedin''' is a group of [[hormones]] that is produced, when stimulated by [[somatotropin]] (STH), to promote cell growth and division <ref>{{eMedicineDictionary|Somatomedin}}</ref>. In this way, they ''mediate'' the effect of somatotropin (also known as [[growth hormone]] <ref>{{eMedicineDictionary|growth+hormone}}</ref>). |
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[[File: 2gf1.jpg|thumb|300 px|Somatomedin C, Human.]] |
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'''Somatomedins''' are a group of proteins produced predominantly by the liver when [[growth hormone]]s act on target tissue. Somatomedins inhibit the release of growth hormones by acting directly on anterior pituitary and by stimulating the secretion of [[somatostatin]] from the hypothalamus. |
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Somatomedins are a group of [[protein]]s that promote cell growth and division in response to stimulation by growth hormone (GH), also known as [[somatotropin]] (STH).<ref>[http://www.emedicinehealth.com/script/main/srchcont_dict.asp?src=Somatomedin Somatomedin] at [[eMedicine]] Dictionary</ref> |
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In addition to their actions that stimulate growth, somatomedins also stimulate production of [[somatostatin]], which suppresses growth hormone release. Thus, levels of somatomedins are controlled via negative feedback through the intermediates of somatostatin and growth hormone. Somatomedins are produced in many tissues and have [[autocrine]] and [[paracrine]] actions in addition to their [[endocrine]] action. The liver is thought to be the predominant source of circulating somatomedins.<ref>Berner Levy Physiology 6th edition|page=723|</ref> |
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Three forms include: |
Three forms include: |
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* [[Somatomedin A]], which is another name for [[insulin-like growth factor 2]] (IGF-2) |
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* [[Somatomedin B]], which is derived from [[vitronectin]]<ref>{{cite journal |author=Zhou A |title=Functional structure of the somatomedin B domain of vitronectin |journal= Protein Science|volume= 16|issue= 7|pages= 1502–8|year=2007 |pmid=17567740 |doi=10.1110/ps.072819107 |pmc=2206693}}</ref> |
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* [[Somatomedin C]], which is another name for [[insulin-like growth factor 1]] (IGF-1) |
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==References== |
==References== |
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==External links== |
==External links== |
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*{{Commons category-inline|Somatomedins}} |
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*{{MeshName|Somatomedins}} |
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* Brs physiology |
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{{Intercellular signaling peptides and proteins}} |
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[[Category:Growth hormones]] |
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[[nl:Somatomedine]] |
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[[ja:ソマトメジン]] |
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Latest revision as of 12:30, 21 February 2022
Somatomedins are a group of proteins produced predominantly by the liver when growth hormones act on target tissue. Somatomedins inhibit the release of growth hormones by acting directly on anterior pituitary and by stimulating the secretion of somatostatin from the hypothalamus.
Somatomedins are a group of proteins that promote cell growth and division in response to stimulation by growth hormone (GH), also known as somatotropin (STH).[1]
Somatomedins have similar biological effects to somatotropin.
In addition to their actions that stimulate growth, somatomedins also stimulate production of somatostatin, which suppresses growth hormone release. Thus, levels of somatomedins are controlled via negative feedback through the intermediates of somatostatin and growth hormone. Somatomedins are produced in many tissues and have autocrine and paracrine actions in addition to their endocrine action. The liver is thought to be the predominant source of circulating somatomedins.[2]
Three forms include:
- Somatomedin A, which is another name for insulin-like growth factor 2 (IGF-2)
- Somatomedin B, which is derived from vitronectin[3]
- Somatomedin C, which is another name for insulin-like growth factor 1 (IGF-1)
References[edit]
- ^ Somatomedin at eMedicine Dictionary
- ^ Berner Levy Physiology 6th edition|page=723|
- ^ Zhou A (2007). "Functional structure of the somatomedin B domain of vitronectin". Protein Science. 16 (7): 1502–8. doi:10.1110/ps.072819107. PMC 2206693. PMID 17567740.
External links[edit]
Media related to Somatomedins at Wikimedia Commons- Somatomedins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Brs physiology
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