MT-ATP8: Difference between revisions
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'''ATP synthase protein 8''' is an [[protein]] that in humans is encoded by the ''MT-ATP8'' [[gene]]. It is a subunit of [[mitochondrial ATPase|mitochondrial ATP synthase]]. |
'''ATP synthase protein 8''' is an [[protein]] that in humans is encoded by the ''MT-ATP8'' [[gene]]. It is a subunit of [[mitochondrial ATPase|mitochondrial ATP synthase]]. |
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This subunit appears to be an integral component of the stator stalk in [[Saccharomyces cerevisiae|yeast]] [[mitochondrial]] [[F-ATPase]]s.<ref name="pmid12626501">{{cite journal | author = Stephens AN, Khan MA, Roucou X, Nagley P, Devenish RJ | title = The molecular neighborhood of subunit 8 of yeast mitochondrial F1F0-ATP synthase probed by cysteine scanning mutagenesis and chemical modification | journal = J. Biol. Chem. | volume = 278 | issue = 20 | pages = 17867–75 |date=May 2003 | pmid = 12626501 | doi = 10.1074/jbc.M300967200 | url = }}</ref> The stator stalk is anchored in the [[membrane]], and acts to prevent futile rotation of the ATPase subunits relative to the rotor during coupled ATP synthesis/hydrolysis. This subunit may have an analogous function in [[Metazoa]]. Subunit 8 differs in [[sequence (biology)|sequence]] between Metazoa, [[plants]] and [[fungus|fungi]] |
This subunit appears to be an integral component of the stator stalk in [[Saccharomyces cerevisiae|yeast]] [[mitochondrial]] [[F-ATPase]]s.<ref name="pmid12626501">{{cite journal | author = Stephens AN, Khan MA, Roucou X, Nagley P, Devenish RJ | title = The molecular neighborhood of subunit 8 of yeast mitochondrial F1F0-ATP synthase probed by cysteine scanning mutagenesis and chemical modification | journal = J. Biol. Chem. | volume = 278 | issue = 20 | pages = 17867–75 |date=May 2003 | pmid = 12626501 | doi = 10.1074/jbc.M300967200 | url = }}</ref> The stator stalk is anchored in the [[membrane]], and acts to prevent futile rotation of the ATPase subunits relative to the rotor during coupled ATP synthesis/hydrolysis. This subunit may have an analogous function in [[Metazoa]]. Subunit 8 differs in [[sequence (biology)|sequence]] between Metazoa, [[plants]] and [[fungus|fungi]]. |
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Revision as of 14:39, 25 January 2016
| ATP synthase protein 8 (metazoa) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | ATP-synt_8 | ||||||||
| Pfam | PF00895 | ||||||||
| Pfam clan | CL0255 | ||||||||
| InterPro | IPR001421 | ||||||||
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| Plant ATP synthase F0 subunit 8 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | YMF19 | ||||||||
| Pfam | PF02326 | ||||||||
| Pfam clan | CL0255 | ||||||||
| InterPro | IPR003319 | ||||||||
| |||||||||
| Fungal ATP synthase protein 8 (A6L) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Fun_ATP-synt_8 | ||||||||
| Pfam | PF05933 | ||||||||
| Pfam clan | CL0255 | ||||||||
| InterPro | IPR009230 | ||||||||
| |||||||||
ATP synthase protein 8 is an protein that in humans is encoded by the MT-ATP8 gene. It is a subunit of mitochondrial ATP synthase.
This subunit appears to be an integral component of the stator stalk in yeast mitochondrial F-ATPases.[1] The stator stalk is anchored in the membrane, and acts to prevent futile rotation of the ATPase subunits relative to the rotor during coupled ATP synthesis/hydrolysis. This subunit may have an analogous function in Metazoa. Subunit 8 differs in sequence between Metazoa, plants and fungi.
References
- ^ Stephens AN, Khan MA, Roucou X, Nagley P, Devenish RJ (May 2003). "The molecular neighborhood of subunit 8 of yeast mitochondrial F1F0-ATP synthase probed by cysteine scanning mutagenesis and chemical modification". J. Biol. Chem. 278 (20): 17867–75. doi:10.1074/jbc.M300967200. PMID 12626501.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
Further reading
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