Somatomedin: Difference between revisions
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Three forms include: |
Three forms include: |
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* somatomedin A, which is another name for [[insulin-like growth factor 2]] (IGF-2) |
* somatomedin A, which is another name for [[insulin-like growth factor 2]] (IGF-2) |
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* [[somatomedin B]], which is derived from [[vitronectin]]<ref>{{cite journal |author=Zhou A |title=Functional structure of the somatomedin B domain of vitronectin |journal= Protein Science|volume= 16|issue= 7|pages= |
* [[somatomedin B]], which is derived from [[vitronectin]]<ref>{{cite journal |author=Zhou A |title=Functional structure of the somatomedin B domain of vitronectin |journal= Protein Science|volume= 16|issue= 7|pages= 1502–8|year=2007 |pmid=17567740 |doi=10.1110/ps.072819107 |pmc=2206693}}</ref> |
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* somatomedin C, which is another name for [[insulin-like growth factor 1]] (IGF-1) |
* somatomedin C, which is another name for [[insulin-like growth factor 1]] (IGF-1) |
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Revision as of 10:08, 18 November 2014
Somatomedins are a group of hormones that promote cell growth and division in response to stimulation by growth hormone (GH), which is also called somatotropin (STH).[1]
They have similar biological effects to somatotropin.somatomedins belong to the insulin family.
In addition to their actions that stimulate growth, somatomedins also stimulate production of somatostatin, which suppresses growth hormone release. Thus, levels of somatomedins are controlled via negative feedback through the intermediates of somatostatin and growth hormone. Somatomedins are produced in many tissues and have autocrine and paracrine actions in addition to their endocrine action. The liver is thought to be the predominant source of circulating somatomedins.[2]
Three forms include:
- somatomedin A, which is another name for insulin-like growth factor 2 (IGF-2)
- somatomedin B, which is derived from vitronectin[3]
- somatomedin C, which is another name for insulin-like growth factor 1 (IGF-1)
References
- ^ Template:EMedicineDictionary
- ^ Berner Levy Physiology 6th edition|page=723|
- ^ Zhou A (2007). "Functional structure of the somatomedin B domain of vitronectin". Protein Science. 16 (7): 1502–8. doi:10.1110/ps.072819107. PMC 2206693. PMID 17567740.
External links
- Somatomedins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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