Somatomedin: Difference between revisions
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Somatomedins are a group of [[hormone]]s that promote cell growth and division in response to stimulation by growth hormone (GH) also known as [[somatotropin]] (STH).<ref>{{eMedicineDictionary|Somatomedin}}</ref> |
Somatomedins are a group of [[hormone]]s that promote cell growth and division in response to stimulation by growth hormone (GH) also known as [[somatotropin]] (STH).<ref>{{eMedicineDictionary|Somatomedin}}</ref> |
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Somatomedins have similar biological effects to [[somatotropin]]. |
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In addition to their actions that stimulate growth, somatomedins also stimulate production of [[somatostatin]], which suppresses growth hormone release. Thus, levels of somatomedins are controlled via negative feedback through the intermediates of somatostatin and growth hormone. Somatomedins are produced in many tissues and have [[autocrine]] and [[paracrine]] actions in addition to their [[endocrine]] action. The liver is thought to be the predominant source of circulating somatomedins.<ref>Berner Levy Physiology 6th edition|page=723|</ref> |
In addition to their actions that stimulate growth, somatomedins also stimulate production of [[somatostatin]], which suppresses growth hormone release. Thus, levels of somatomedins are controlled via negative feedback through the intermediates of somatostatin and growth hormone. Somatomedins are produced in many tissues and have [[autocrine]] and [[paracrine]] actions in addition to their [[endocrine]] action. The liver is thought to be the predominant source of circulating somatomedins.<ref>Berner Levy Physiology 6th edition|page=723|</ref> |
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Revision as of 18:15, 18 December 2014
Somatomedins are produced, predominantly by the liver, when growth hormones act on target tissue. Somatomedins inhibit the release of growth hormones by acting directly on anterior pituitary and by stimulating the secretion of somatostatin from the hypothalamus.
Somatomedins are a group of hormones that promote cell growth and division in response to stimulation by growth hormone (GH) also known as somatotropin (STH).[1]
Somatomedins have similar biological effects to somatotropin.
In addition to their actions that stimulate growth, somatomedins also stimulate production of somatostatin, which suppresses growth hormone release. Thus, levels of somatomedins are controlled via negative feedback through the intermediates of somatostatin and growth hormone. Somatomedins are produced in many tissues and have autocrine and paracrine actions in addition to their endocrine action. The liver is thought to be the predominant source of circulating somatomedins.[2]
Three forms include:
- somatomedin A, which is another name for insulin-like growth factor 2 (IGF-2)
- somatomedin B, which is derived from vitronectin[3]
- somatomedin C, which is another name for insulin-like growth factor 1 (IGF-1)
References
- ^ Template:EMedicineDictionary
- ^ Berner Levy Physiology 6th edition|page=723|
- ^ Zhou A (2007). "Functional structure of the somatomedin B domain of vitronectin". Protein Science. 16 (7): 1502–8. doi:10.1110/ps.072819107. PMC 2206693. PMID 17567740.
External links
- Somatomedins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Brs physiology
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