Boswellia serrata: Difference between revisions

From Wikipedia, the free encyclopedia
Browse history interactively
← Previous editNext edit →
Content deleted Content added
VisualWikitext
Nlaeditor (talk | contribs)
29 edits
m →‎Active constituents: Added a detail about AKBA.
Nlaeditor (talk | contribs)
29 edits
→‎Active constituents: Added supporting reference.
Line 26: Line 26:


=== Active constituents ===
=== Active constituents ===
Boswellia serrata contains chemical constituents mainly β-boswellic acid, acetyl-β-boswellic acid, 11-keto-β-boswellic acid and acetyl-11-keto-β-boswellic acid.<ref>{{Cite journal|last=Dragos|first=Dorin|last2=Gilca|first2=Marilena|last3=Gaman|first3=Laura|last4=Vlad|first4=Adelina|last5=Iosif|first5=Liviu|last6=Stoian|first6=Irina|last7=Lupescu|first7=Olivera|date=2017-01-16|title=Phytomedicine in Joint Disorders|journal=Nutrients|volume=9|issue=1|doi=10.3390/nu9010070|issn=2072-6643|pmc=5295114|pmid=28275210}}</ref> Acetyl-11-keto-β-boswellic acid (AKBA) is the most potent 5-lipoxygenase enzyme inhibitor which is responsible for inflammation.<ref>{{Cite journal|last=Siddiqui|first=M. Z.|date=May 2011|title=Boswellia serrata, a potential antiinflammatory agent: an overview 7|journal=Indian Journal of Pharmaceutical Sciences|volume=73|issue=3|pages=255–261|doi=10.4103/0250-474X.93507 |pmc=3309643|pmid=22457547}}</ref> AKBA is a compound associated with stopping 5-lipoxygenase (5-LOX) inflammation.
Boswellia serrata contains chemical constituents mainly β-boswellic acid, acetyl-β-boswellic acid, 11-keto-β-boswellic acid and acetyl-11-keto-β-boswellic acid.<ref>{{Cite journal|last=Dragos|first=Dorin|last2=Gilca|first2=Marilena|last3=Gaman|first3=Laura|last4=Vlad|first4=Adelina|last5=Iosif|first5=Liviu|last6=Stoian|first6=Irina|last7=Lupescu|first7=Olivera|date=2017-01-16|title=Phytomedicine in Joint Disorders|journal=Nutrients|volume=9|issue=1|doi=10.3390/nu9010070|issn=2072-6643|pmc=5295114|pmid=28275210}}</ref> Acetyl-11-keto-β-boswellic acid (AKBA) is the most potent 5-lipoxygenase enzyme inhibitor which is responsible for inflammation.<ref>{{Cite journal|last=Siddiqui|first=M. Z.|date=May 2011|title=Boswellia serrata, a potential antiinflammatory agent: an overview 7|journal=Indian Journal of Pharmaceutical Sciences|volume=73|issue=3|pages=255–261|doi=10.4103/0250-474X.93507 |pmc=3309643|pmid=22457547}}</ref> AKBA is a compound associated with stopping 5-lipoxygenase (5-LOX) inflammation.<ref>{{Cite journal|last=Meka|first=B. Z.|date=Feb 2017|title=Synthesis of new analogs of AKBA and evaluation of their anti-inflammatory activities 7|journal=Bioorganic & Medicinal Chemistry|volume=25|issue=4|pages=1374-1388|doi: 10.1016/j.bmc.2016.12.045}}</ref> AKBA is a compound associated with stopping 5-lipoxygenase (5-LOX) inflammation.


== References ==
== References ==

Revision as of 17:11, 7 June 2018

Boswellia serrata
in Kinnerasani Wildlife Sanctuary, Andhra Pradesh, India.
Scientific classification Edit this classification
Kingdom: Plantae
Clade: Tracheophytes
Clade: Angiosperms
Clade: Eudicots
Clade: Rosids
Order: Sapindales
Family: Burseraceae
Genus: Boswellia
Species:
B. serrata
Binomial name
Boswellia serrata

Boswellia serrata is a plant that produces Indian frankincense, Salai, referred to in Sanskrit as shallaki and in Latin as Olibanum Indicum.[1] the plant is native to much of India and the Punjab region that extends into Pakistan.[2] Boswellia serrata Roxb., is also known as ‘Indian olibanum’, ‘Indian frankincense’, ‘dhup’ and ‘salai’ or ‘salai guggul’ is found in Eastern India.[3]

Medical usage

In Ayurvedic medicine Indian frankincense has been used for hundreds of years for the treatment of arthritis.[4][5]

in Kinnerasani Wildlife Sanctuary, Andhra Pradesh, India.

Extracts of Boswellia serrata have been clinically studied for osteoarthritis and joint function, particularly for osteoarthritis of the knee, with the research showing a slight improvement of both pain and function compared to a placebo.[6] Positive effects of Boswellia in some chronic inflammatory diseases including rheumatoid arthritis, bronchial asthma, osteoarthritis, ulcerative colitis and Crohn's disease have been reported.[7] Some see Boswellia serrata as a promising alternative to NSAIDs, warranting further investigation in pharmacological studies and clinical trials.[8][9] It is also used in Iranian traditional medicine for diabetes.[10]

Topical application

Boswellia serrata has been recently developed for topical use in a patent-pending formula in Sano Relief Gel. Boswellia serrata is used in the manufacture of the anti-wrinkle agent "Boswelox",[11] which has been criticised as being ineffective.[12]

Active constituents

Boswellia serrata contains chemical constituents mainly β-boswellic acid, acetyl-β-boswellic acid, 11-keto-β-boswellic acid and acetyl-11-keto-β-boswellic acid.[13] Acetyl-11-keto-β-boswellic acid (AKBA) is the most potent 5-lipoxygenase enzyme inhibitor which is responsible for inflammation.[14] AKBA is a compound associated with stopping 5-lipoxygenase (5-LOX) inflammation.[15] AKBA is a compound associated with stopping 5-lipoxygenase (5-LOX) inflammation.

References

  1. ^ European Scientific Cooperative on Phytotherapy (2009). E/S/C/O/P Monographs: The Scientific Foundation for Herbal Medicinal Products. Second Edition, Supplement 2009. European Scientific Cooperative on Phytotherapy. p. 184. ISBN 9781901964080.
  2. ^ "Boswellia serrata". Germplasm Resources Information Network. Agricultural Research Service, United States Department of Agriculture. Retrieved 15 October 2014.
  3. ^ Siddiqui, M. Z. (May 2011). "Boswellia serrata, a potential antiinflammatory agent: an overview". Indian Journal of Pharmaceutical Sciences. 73 (3): 255–261. doi:10.4103/0250-474X.93507. PMC 3309643. PMID 22457547.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  4. ^ "JOINT RELIEF". www.herbcompanion.com. Retrieved 2009-01-12.
  5. ^ https://americanindianimports.com/content/9_shallaki-natural-anti-inflammatory
  6. ^ Cameron, M; Chrubasik, S (May 22, 2014). "Oral herbal therapies for treating osteoarthritis". Cochrane Summaries. Retrieved June 6, 2014.
  7. ^ Ammon, HP (2010). "Modulation of the immune system by Boswellia serrata extracts and boswellic acids". Phytomedicine. 17 (11): 862–7. doi:10.1016/j.phymed.2010.03.003.
  8. ^ Abdel-Tawab, M; Werz, O; Schubert-Zsilavecz, M (Jun 2011). "Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data". Clin Pharmacokinet. 50 (6): 349–69. doi:10.2165/11586800-000000000-00000. PMID 21553931.
  9. ^ Siddiqui, MZ (2011). "Boswellia serrata, a potential antiinflammatory agent: an overview". Indian J Pharm Sci. 73: 255–61. doi:10.4103/0250-474X.93507. PMC 3309643. PMID 22457547.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  10. ^ "The Effects of Boswellia serrata Gum Resin on the Blood Glucose and Lipid Profile of Diabetic Patients: A Double-Blind Randomized Placebo-Controlled Clinical Trial". doi:10.1177/2515690X18772728. PMID 29774768. {{cite journal}}: Cite journal requires |journal= (help)
  11. ^ Wrinkle breakthrough claim from L'Oreal
  12. ^ L'Oreal slammed over cream claims
  13. ^ Dragos, Dorin; Gilca, Marilena; Gaman, Laura; Vlad, Adelina; Iosif, Liviu; Stoian, Irina; Lupescu, Olivera (2017-01-16). "Phytomedicine in Joint Disorders". Nutrients. 9 (1). doi:10.3390/nu9010070. ISSN 2072-6643. PMC 5295114. PMID 28275210.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  14. ^ Siddiqui, M. Z. (May 2011). "Boswellia serrata, a potential antiinflammatory agent: an overview 7". Indian Journal of Pharmaceutical Sciences. 73 (3): 255–261. doi:10.4103/0250-474X.93507. PMC 3309643. PMID 22457547.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  15. ^ Meka, B. Z. (Feb 2017). "Synthesis of new analogs of AKBA and evaluation of their anti-inflammatory activities 7". Bioorganic & Medicinal Chemistry. 25 (4): 1374–1388. {{cite journal}}: Text "doi: 10.1016/j.bmc.2016.12.045" ignored (help)
Retrieved from "https://en.wikipedia.org/w/index.php?title=Boswellia_serrata&oldid=844858989"