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Salai guggul useful in Chikungunya patients for joint pain relief
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[[Image:Boswellia serrata (Salai) in Kinnarsani WS, AP W IMG_5843.jpg|thumb|250px|left|in [[Kinnerasani Wildlife Sanctuary]], [[Andhra Pradesh]], [[India]]. ]]
[[Image:Boswellia serrata (Salai) in Kinnarsani WS, AP W IMG_5843.jpg|thumb|250px|left|in [[Kinnerasani Wildlife Sanctuary]], [[Andhra Pradesh]], [[India]]. ]]
Extracts of ''Boswellia serrata'' have been clinically studied for [[osteoarthritis]] and joint function, particularly for osteoarthritis of the knee, with the research showing a slight improvement of both pain and function compared to a placebo.<ref>{{cite web |first1=M |last1=Cameron |first2=S |last2=Chrubasik |title=Oral herbal therapies for treating osteoarthritis |publisher=Cochrane Summaries |date=May 22, 2014 |url=http://summaries.cochrane.org/CD002947/oral-herbal-therapies-for-treating-osteoarthritis |accessdate=June 6, 2014}}</ref> Positive effects of ''Boswellia'' in some chronic inflammatory diseases including [[rheumatoid arthritis]], [[Asthma|bronchial asthma]], osteoarthritis, [[ulcerative colitis]] and [[Crohn's disease]] have been reported.<ref>{{cite journal | last1 = Ammon | first1 = HP | year = 2010 | title = Modulation of the immune system by Boswellia serrata extracts and boswellic acids | url = | journal = Phytomedicine | volume = 17 | issue = 11| pages = 862–7 | doi=10.1016/j.phymed.2010.03.003}}</ref> Some see ''Boswellia serrata'' as a promising alternative to [[NSAIDs]], warranting further investigation in pharmacological studies and clinical trials.<ref>{{cite journal | last1 = Abdel-Tawab | first1 = M | last2 = Werz | first2 = O | last3 = Schubert-Zsilavecz | first3 = M | date = Jun 2011 | title = Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data | url = | journal = Clin Pharmacokinet | volume = 50 | issue = 6| pages = 349–69 | doi=10.2165/11586800-000000000-00000 | pmid=21553931}}</ref><ref>{{cite journal | pmc = 3309643 | pmid=22457547 | doi=10.4103/0250-474X.93507 | volume=73 | title=Boswellia serrata, a potential antiinflammatory agent: an overview | year=2011 | journal=Indian J Pharm Sci | pages=255–61 | last1 = Siddiqui | first1 = MZ}}</ref> It is also used in [[Iranian traditional medicine]] for [[diabetes]].<ref>{{cite journal|title=The Effects of Boswellia serrata Gum Resin on the Blood Glucose and Lipid Profile of Diabetic Patients: A Double-Blind Randomized Placebo-Controlled Clinical Trial.|doi=10.1177/2515690X18772728|pmid=29774768|url=http://journals.sagepub.com/doi/abs/10.1177/2515690X18772728?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed}}</ref>
Extracts of ''Boswellia serrata'' have been clinically studied for [[osteoarthritis]] and joint function, particularly for osteoarthritis of the knee, with the research showing a slight improvement of both pain and function compared to a placebo.<ref>{{cite web |first1=M |last1=Cameron |first2=S |last2=Chrubasik |title=Oral herbal therapies for treating osteoarthritis |publisher=Cochrane Summaries |date=May 22, 2014 |url=http://summaries.cochrane.org/CD002947/oral-herbal-therapies-for-treating-osteoarthritis |accessdate=June 6, 2014}}</ref> Positive effects of ''Boswellia'' in some chronic inflammatory diseases including [[rheumatoid arthritis]], [[Asthma|bronchial asthma]], osteoarthritis, [[ulcerative colitis]] and [[Crohn's disease]] have been reported.<ref>{{cite journal | last1 = Ammon | first1 = HP | year = 2010 | title = Modulation of the immune system by Boswellia serrata extracts and boswellic acids | url = | journal = Phytomedicine | volume = 17 | issue = 11| pages = 862–7 | doi=10.1016/j.phymed.2010.03.003}}</ref> Some see ''Boswellia serrata'' as a promising alternative to [[NSAIDs]], warranting further investigation in pharmacological studies and clinical trials.<ref>{{cite journal | last1 = Abdel-Tawab | first1 = M | last2 = Werz | first2 = O | last3 = Schubert-Zsilavecz | first3 = M | date = Jun 2011 | title = Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data | url = | journal = Clin Pharmacokinet | volume = 50 | issue = 6| pages = 349–69 | doi=10.2165/11586800-000000000-00000 | pmid=21553931}}</ref><ref>{{cite journal | pmc = 3309643 | pmid=22457547 | doi=10.4103/0250-474X.93507 | volume=73 | title=Boswellia serrata, a potential antiinflammatory agent: an overview | year=2011 | journal=Indian J Pharm Sci | pages=255–61 | last1 = Siddiqui | first1 = MZ}}</ref> It is also used in [[Iranian traditional medicine]] for [[diabetes]].<ref>{{cite journal|title=The Effects of Boswellia serrata Gum Resin on the Blood Glucose and Lipid Profile of Diabetic Patients: A Double-Blind Randomized Placebo-Controlled Clinical Trial.|doi=10.1177/2515690X18772728|pmid=29774768|url=http://journals.sagepub.com/doi/abs/10.1177/2515690X18772728?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed}}</ref>

Now a day it is most useful in chikungunya patient. Who have severe pain in joint and muscle. Sallaki tablet contain 400mg salai guggul and giving good result pain joint and muscle pain.


=== Topical application===
=== Topical application===

Revision as of 07:25, 7 October 2018

Boswellia serrata
in Kinnerasani Wildlife Sanctuary, Andhra Pradesh, India.
Scientific classification Edit this classification
Kingdom: Plantae
Clade: Tracheophytes
Clade: Angiosperms
Clade: Eudicots
Clade: Rosids
Order: Sapindales
Family: Burseraceae
Genus: Boswellia
Species:
B. serrata
Binomial name
Boswellia serrata

Boswellia serrata is a plant that produces Indian frankincense, Salai, referred to in Sanskrit as shallaki and in Latin as Olibanum Indicum.[1] the plant is native to much of India and the Punjab region that extends into Pakistan.[2] Boswellia serrata Roxb., is also known as ‘Indian olibanum’, ‘Indian frankincense’, ‘dhup’ and ‘salai’ or ‘salai guggul’ is found in Eastern India.[3]

Medical usage

In Ayurvedic medicine Indian frankincense has been used for hundreds of years for the treatment of arthritis.[4][5]

in Kinnerasani Wildlife Sanctuary, Andhra Pradesh, India.

Extracts of Boswellia serrata have been clinically studied for osteoarthritis and joint function, particularly for osteoarthritis of the knee, with the research showing a slight improvement of both pain and function compared to a placebo.[6] Positive effects of Boswellia in some chronic inflammatory diseases including rheumatoid arthritis, bronchial asthma, osteoarthritis, ulcerative colitis and Crohn's disease have been reported.[7] Some see Boswellia serrata as a promising alternative to NSAIDs, warranting further investigation in pharmacological studies and clinical trials.[8][9] It is also used in Iranian traditional medicine for diabetes.[10]

Topical application

Boswellia serrata has been recently developed for topical use in a patent-pending formula in Sano Relief Gel. Boswellia serrata is used in the manufacture of the anti-wrinkle agent "Boswelox",[11] which has been criticised as being ineffective.[12]

Active constituents

Boswellia serrata contains chemical constituents mainly β-boswellic acid, acetyl-β-boswellic acid, 11-keto-β-boswellic acid and acetyl-11-keto-β-boswellic acid.[13] Acetyl-11-keto-β-boswellic acid (AKBA) is the most potent 5-lipoxygenase enzyme inhibitor which is responsible for inflammation.[14] AKBA is a compound associated with stopping 5-lipoxygenase (5-LOX) inflammation.[15]

References

  1. ^ European Scientific Cooperative on Phytotherapy (2009). E/S/C/O/P Monographs: The Scientific Foundation for Herbal Medicinal Products. Second Edition, Supplement 2009. European Scientific Cooperative on Phytotherapy. p. 184. ISBN 9781901964080.
  2. ^ "Boswellia serrata". Germplasm Resources Information Network. Agricultural Research Service, United States Department of Agriculture. Retrieved 15 October 2014.
  3. ^ Siddiqui, M. Z. (May 2011). "Boswellia serrata, a potential antiinflammatory agent: an overview". Indian Journal of Pharmaceutical Sciences. 73 (3): 255–261. doi:10.4103/0250-474X.93507. PMC 3309643. PMID 22457547.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  4. ^ "JOINT RELIEF". www.herbcompanion.com. Retrieved 2009-01-12.
  5. ^ https://americanindianimports.com/content/9_shallaki-natural-anti-inflammatory
  6. ^ Cameron, M; Chrubasik, S (May 22, 2014). "Oral herbal therapies for treating osteoarthritis". Cochrane Summaries. Retrieved June 6, 2014.
  7. ^ Ammon, HP (2010). "Modulation of the immune system by Boswellia serrata extracts and boswellic acids". Phytomedicine. 17 (11): 862–7. doi:10.1016/j.phymed.2010.03.003.
  8. ^ Abdel-Tawab, M; Werz, O; Schubert-Zsilavecz, M (Jun 2011). "Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data". Clin Pharmacokinet. 50 (6): 349–69. doi:10.2165/11586800-000000000-00000. PMID 21553931.
  9. ^ Siddiqui, MZ (2011). "Boswellia serrata, a potential antiinflammatory agent: an overview". Indian J Pharm Sci. 73: 255–61. doi:10.4103/0250-474X.93507. PMC 3309643. PMID 22457547.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  10. ^ "The Effects of Boswellia serrata Gum Resin on the Blood Glucose and Lipid Profile of Diabetic Patients: A Double-Blind Randomized Placebo-Controlled Clinical Trial". doi:10.1177/2515690X18772728. PMID 29774768. {{cite journal}}: Cite journal requires |journal= (help)
  11. ^ Wrinkle breakthrough claim from L'Oreal
  12. ^ L'Oreal slammed over cream claims
  13. ^ Dragos, Dorin; Gilca, Marilena; Gaman, Laura; Vlad, Adelina; Iosif, Liviu; Stoian, Irina; Lupescu, Olivera (2017-01-16). "Phytomedicine in Joint Disorders". Nutrients. 9 (1). doi:10.3390/nu9010070. ISSN 2072-6643. PMC 5295114. PMID 28275210.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  14. ^ Siddiqui, M. Z. (May 2011). "Boswellia serrata, a potential antiinflammatory agent: an overview 7". Indian Journal of Pharmaceutical Sciences. 73 (3): 255–261. doi:10.4103/0250-474X.93507. PMC 3309643. PMID 22457547.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  15. ^ Meka, B. Z. (Feb 2017). "Synthesis of new analogs of AKBA and evaluation of their anti-inflammatory activities 7". Bioorganic & Medicinal Chemistry. 25 (4): 1374–1388. doi:10.1016/j.bmc.2016.12.045. PMID 28110820.
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