MT-ATP8

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ATP synthase protein 8 (metazoa)
Identifiers
SymbolATP-synt_8
PfamPF00895
Pfam clanCL0255
InterProIPR001421
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
Plant ATP synthase F0 subunit 8
Identifiers
SymbolYMF19
PfamPF02326
Pfam clanCL0255
InterProIPR003319
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
Fungal ATP synthase protein 8 (A6L)
Identifiers
SymbolFun_ATP-synt_8
PfamPF05933
Pfam clanCL0255
InterProIPR009230
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

ATP synthase protein 8 is an protein that in humans is encoded in the mitochondrial genome by the MT-ATP8 gene. It is a subunit of mitochondrial ATP synthase.

This subunit appears to be an integral component of the stator stalk in yeast mitochondrial F-ATPases.[1] The stator stalk is anchored in the membrane, and acts to prevent futile rotation of the ATPase subunits relative to the rotor during coupled ATP synthesis/hydrolysis. This subunit may have an analogous function in Metazoa. Subunit 8 differs in sequence between Metazoa, plants and fungi.

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References

  1. ^ Stephens AN, Khan MA, Roucou X, Nagley P, Devenish RJ (May 2003). "The molecular neighborhood of subunit 8 of yeast mitochondrial F1F0-ATP synthase probed by cysteine scanning mutagenesis and chemical modification". J. Biol. Chem. 278 (20): 17867–75. doi:10.1074/jbc.M300967200. PMID 12626501.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)

Further reading

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This article incorporates text from the public domain Pfam and InterPro: IPR001421