Neurophysin II: Difference between revisions

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Structures	Swiss-model
Domains	InterPro

arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal)
arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal)
Identifiers
Symbol	AVP
Alt. symbols	ARVP
NCBI gene	551
HGNC	894
OMIM	192340
RefSeq	NM_000490
UniProt	P01185
Other data
Locus	Chr. 20 p13
Structures
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Structures	Swiss-model
Domains	InterPro

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Revision as of 14:37, 11 March 2010

Neurophysin II is a carrier protein which binds vasopressin. It is generated from the same precursor as vasopressin.

It can be associated with neurohypophyseal diabetes insipidus.^[1]

Neurophysin II is also known as a stimulator of Prolactin secretion.

Clinical significance

Point mutations in neurophysin II underline most cases of hereditary hypothalamicdiabetes insipidus, a disorder resulting from insufficient ADH release into systemic circulation.

References

^ Christensen JH, Siggaard C, Corydon TJ; et al. (2004). "Six novel mutations in the arginine vasopressin gene in 15 kindreds with autosomal dominant familial neurohypophyseal diabetes insipidus give further insight into the pathogenesis". Eur. J. Hum. Genet. 12 (1): 44–51. doi:10.1038/sj.ejhg.5201086. PMID 14673472. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

External links

Neurophysin+II at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This biochemistry article is a stub. You can help Wikipedia by expanding it.

[pmid14673472-1] Christensen JH, Siggaard C, Corydon TJ; et al. (2004). "Six novel mutations in the arginine vasopressin gene in 15 kindreds with autosomal dominant familial neurohypophyseal diabetes insipidus give further insight into the pathogenesis". Eur. J. Hum. Genet. 12 (1): 44–51. doi:10.1038/sj.ejhg.5201086. PMID 14673472. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

[1]

@@ Line 26: / Line 26: @@
 == Clinical significance ==
-Point mutations in neurophysin II underline most cases of hereditary [[hypothalamic diabetes insipidus]], a disorder resulting from insufficient ADH release into systemic circulation.
+Point mutations in neurophysin II underline most cases of hereditary hypothalamic[[ diabetes insipidus]], a disorder resulting from insufficient ADH release into systemic circulation.
 ==References==

v t e Proteins: carrier proteins
Fatty acid	FABP1 FABP2 FABP3 FABP4 FABP5 FABP6 FABP7
Hormone	peptide hormone: Follistatin Growth hormone binding protein Insulin-like growth factor binding protein IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 Neurophysins Neurophysin I II steroid hormone: Sex hormone binding globulin/Androgen binding protein Transcortin Thyroxine-binding globulin Transthyretin
Metal/element	calcium Calcium-binding protein Calmodulin-binding proteins copper Ceruloplasmin iron Iron-binding proteins Transferrin receptor
Vitamin	Retinol binding protein 1 2 3 4 Transcobalamin
Pigment	Plant Light-Harvesting Complex Orange Carotenoid Protein Phycobiliprotein Photosynthetic Reaction Centers Phytochrome Rhodopsin
Other	Acyl carrier protein Adaptor protein Cholesterylester transfer protein F-box protein GTP-binding protein Latent TGF-beta binding protein Major urinary proteins Membrane transport protein Odorant binding protein