Neurophysin II: Difference between revisions
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Neurophysin II is also known as a stimulator of [[Prolactin]] secretion. |
Neurophysin II is also known as a stimulator of [[Prolactin]] secretion. |
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== Structure == |
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The amino acid sequence of Neurophysin II is: |
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NH<sub>2</sub> - Ala - Met - Ser - Asp - Leu - Glu - Leu - Arg - Gln - Cys - Leu - Pro - Cys - Gly - Pro - Gly - Gly - Lys - Gly - Arg - Cys - Phe - Gly - Pro - Ser - Ile - Cys - Cys - Ala - Asp - Glu - Leu - Gly - Cys - Phe - Val - Gly - Thr - Ala - Glu - Ala - Leu - Arg - Cys - Gln - Glu - Glu - Asn - Tyr - Leu - Pro - Ser - Pro - Cys - Gln - Ser - Gly - Gln - Lys - Ala - Cys - Gly - Ser - Gly - Gly - Arg - Cys - Ala - Ala - Phe - Gly - Val - Cys - Cys - Asn - Asp - Glu - Ser - Cys - Val - Thr - Glu - Pro - Glu - Cys - Arg - Glu - Gly - Phe - His - Arg - Arg - Ala - OH |
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(Disulfide - bridge: - 10-54; - 13-27; - 21-44; - 28-34; - 61-73; - 67-85; - 74-79) |
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== Clinical significance == |
== Clinical significance == |
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Revision as of 04:45, 3 August 2011
| arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | AVP | ||||||
| Alt. symbols | ARVP | ||||||
| NCBI gene | 551 | ||||||
| HGNC | 894 | ||||||
| OMIM | 192340 | ||||||
| RefSeq | NM_000490 | ||||||
| UniProt | P01185 | ||||||
| Other data | |||||||
| Locus | Chr. 20 p13 | ||||||
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Neurophysin II is a carrier protein which binds vasopressin. It is generated from the same precursor as vasopressin.
It can be associated with neurohypophyseal diabetes insipidus.[1]
Neurophysin II is also known as a stimulator of Prolactin secretion.
Structure
The amino acid sequence of Neurophysin II is:
NH2 - Ala - Met - Ser - Asp - Leu - Glu - Leu - Arg - Gln - Cys - Leu - Pro - Cys - Gly - Pro - Gly - Gly - Lys - Gly - Arg - Cys - Phe - Gly - Pro - Ser - Ile - Cys - Cys - Ala - Asp - Glu - Leu - Gly - Cys - Phe - Val - Gly - Thr - Ala - Glu - Ala - Leu - Arg - Cys - Gln - Glu - Glu - Asn - Tyr - Leu - Pro - Ser - Pro - Cys - Gln - Ser - Gly - Gln - Lys - Ala - Cys - Gly - Ser - Gly - Gly - Arg - Cys - Ala - Ala - Phe - Gly - Val - Cys - Cys - Asn - Asp - Glu - Ser - Cys - Val - Thr - Glu - Pro - Glu - Cys - Arg - Glu - Gly - Phe - His - Arg - Arg - Ala - OH
(Disulfide - bridge: - 10-54; - 13-27; - 21-44; - 28-34; - 61-73; - 67-85; - 74-79)
Clinical significance
Point mutations in neurophysin II underline most cases of hereditary hypothalamic diabetes insipidus, a disorder resulting from insufficient ADH release into systemic circulation.
References
- ^ Christensen JH, Siggaard C, Corydon TJ; et al. (2004). "Six novel mutations in the arginine vasopressin gene in 15 kindreds with autosomal dominant familial neurohypophyseal diabetes insipidus give further insight into the pathogenesis". Eur. J. Hum. Genet. 12 (1): 44–51. doi:10.1038/sj.ejhg.5201086. PMID 14673472.
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External links
- Neurophysin+II at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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