Neurophysin II: Difference between revisions
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'''Neurophysin II''' is a [[carrier protein]] which binds [[vasopressin]]. It is generated from the same precursor as vasopressin. |
'''Neurophysin II''' is a [[carrier protein]] which binds [[vasopressin]]. It is generated from the same precursor as vasopressin. |
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It can be associated with [[neurohypophyseal diabetes insipidus]].<ref name="pmid14673472">{{cite journal |author=Christensen JH, Siggaard C, Corydon TJ, ''et al'' |title=Six novel mutations in the arginine vasopressin gene in 15 kindreds with autosomal dominant familial neurohypophyseal diabetes insipidus give further insight into the pathogenesis |journal=Eur. J. Hum. Genet. |volume=12 |issue=1 |pages=44–51 | |
It can be associated with [[neurohypophyseal diabetes insipidus]].<ref name="pmid14673472">{{cite journal |author=Christensen JH, Siggaard C, Corydon TJ, ''et al'' |title=Six novel mutations in the arginine vasopressin gene in 15 kindreds with autosomal dominant familial neurohypophyseal diabetes insipidus give further insight into the pathogenesis |journal=Eur. J. Hum. Genet. |volume=12 |issue=1 |pages=44–51 |date=January 2004 |pmid=14673472 |doi=10.1038/sj.ejhg.5201086}}</ref> |
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Neurophysin II is also known as a stimulator of [[Prolactin]] secretion. |
Neurophysin II is also known as a stimulator of [[Prolactin]] secretion. |
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Revision as of 13:07, 27 January 2014
| arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | AVP | ||||||
| Alt. symbols | ARVP | ||||||
| NCBI gene | 551 | ||||||
| HGNC | 894 | ||||||
| OMIM | 192340 | ||||||
| RefSeq | NM_000490 | ||||||
| UniProt | P01185 | ||||||
| Other data | |||||||
| Locus | Chr. 20 p13 | ||||||
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Neurophysin II is a carrier protein which binds vasopressin. It is generated from the same precursor as vasopressin.
It can be associated with neurohypophyseal diabetes insipidus.[1]
Neurophysin II is also known as a stimulator of Prolactin secretion.
Structure
The amino acid sequence of Neurophysin II is:
NH2 - Ala - Met - Ser - Asp - Leu - Glu - Leu - Arg - Gln - Cys - Leu - Pro - Cys - Gly - Pro - Gly - Gly - Lys - Gly - Arg - Cys - Phe - Gly - Pro - Ser - Ile - Cys - Cys - Ala - Asp - Glu - Leu - Gly - Cys - Phe - Val - Gly - Thr - Ala - Glu - Ala - Leu - Arg - Cys - Gln - Glu - Glu - Asn - Tyr - Leu - Pro - Ser - Pro - Cys - Gln - Ser - Gly - Gln - Lys - Ala - Cys - Gly - Ser - Gly - Gly - Arg - Cys - Ala - Ala - Phe - Gly - Val - Cys - Cys - Asn - Asp - Glu - Ser - Cys - Val - Thr - Glu - Pro - Glu - Cys - Arg - Glu - Gly - Phe - His - Arg - Arg - Ala - OH
(Disulfide - bridge: - 10-54; - 13-27; - 21-44; - 28-34; - 61-73; - 67-85; - 74-79)
Clinical significance
Point mutations in neurophysin II underline most cases of hereditary hypothalamic diabetes insipidus, a disorder resulting from insufficient ADH release into systemic circulation.
References
- ^ Christensen JH, Siggaard C, Corydon TJ; et al. (January 2004). "Six novel mutations in the arginine vasopressin gene in 15 kindreds with autosomal dominant familial neurohypophyseal diabetes insipidus give further insight into the pathogenesis". Eur. J. Hum. Genet. 12 (1): 44–51. doi:10.1038/sj.ejhg.5201086. PMID 14673472.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link)
External links
- Neurophysin+II at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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