Neurophysin II
| arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | AVP | ||||||
| Alt. symbols | ARVP | ||||||
| NCBI gene | 551 | ||||||
| HGNC | 894 | ||||||
| OMIM | 192340 | ||||||
| RefSeq | NM_000490 | ||||||
| UniProt | P01185 | ||||||
| Other data | |||||||
| Locus | Chr. 20 p13 | ||||||
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Neurophysin II is a carrier protein which binds vasopressin. It is generated from the same precursor as vasopressin.
It can be associated with neurohypophyseal diabetes insipidus.[1]
Neurophysin II is also known as a stimulator of Prolactin secretion.
Clinical significance
Point mutations in neurophysin II underline most cases of hereditary hypothalamicdiabetes insipidus, a disorder resulting from insufficient ADH release into systemic circulation.
References
- ^ Christensen JH, Siggaard C, Corydon TJ; et al. (2004). "Six novel mutations in the arginine vasopressin gene in 15 kindreds with autosomal dominant familial neurohypophyseal diabetes insipidus give further insight into the pathogenesis". Eur. J. Hum. Genet. 12 (1): 44–51. doi:10.1038/sj.ejhg.5201086. PMID 14673472.
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External links
- Neurophysin+II at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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