RTL3: Difference between revisions
Content deleted Content added
→Function: Fixed reference date error(s) (see CS1 errors: dates for details) and AWB general fixes |
consistent citation formatting; combined repeated citations |
||
| Line 7: | Line 7: | ||
| title = Entrez Gene: Retrotransposon Gag like 3 |
| title = Entrez Gene: Retrotransposon Gag like 3 |
||
| url = https://www.ncbi.nlm.nih.gov/gene/203430 |
| url = https://www.ncbi.nlm.nih.gov/gene/203430 |
||
| |
| access-date = 2017-09-18 |
||
}}</ref> |
}}</ref> |
||
==Function== |
== Function == |
||
This gene is a member of a family of gag-related retrotransposon genes. These genes appear to have lost the ability to retrotranspose; however, their open reading frames have remained intact, which may indicate that these genes have acquired new functions in the cell. Retrotransposon gag-like-3 (RTL3/ZCCHC5/MART3) is one of eleven Sushi-like neogenes identified in the human genome7 RTL3 encodes a 53 kDa protein with a nucleic acid-binding domain (CX2CX4HX4C), gag-like region within the open reading frame and an ssDNA/RNA-binding homeobox-associated leucine zipper motif.<ref>{{ |
This gene is a member of a family of gag-related retrotransposon genes. These genes appear to have lost the ability to retrotranspose; however, their open reading frames have remained intact, which may indicate that these genes have acquired new functions in the cell. Retrotransposon gag-like-3 (RTL3/ZCCHC5/MART3) is one of eleven Sushi-like neogenes identified in the human genome7 RTL3 encodes a 53 kDa protein with a nucleic acid-binding domain (CX2CX4HX4C), gag-like region within the open reading frame and an ssDNA/RNA-binding homeobox-associated leucine zipper motif.<ref name = "Ball_2021">{{cite journal | vauthors = Ball HC, Ansari MY, Ahmad N, Novak K, Haqqi TM | title = A retrotransposon gag-like-3 gene RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes | journal = Connective Tissue Research | volume = 62 | issue = 6 | pages = 615–628 | date = November 2021 | pmid = 33043724 | pmc = 8404968 | doi = 10.1080/03008207.2020.1828380 }}</ref> It has been reported that RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes.<ref name = "Ball_2021" /> |
||
== References == |
== References == |
||
{{reflist}} |
{{reflist}} |
||
== Further reading == |
|||
{{refbegin | 2}} |
|||
{{refend}} |
|||
{{NLM content}} |
{{NLM content}} |
||
{{gene-X-stub}} |
{{gene-X-stub}} |
||
Revision as of 17:49, 9 December 2023
| RTL3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | RTL3, Mar3, Mart3, ZHC5, ZCCHC5, zinc finger CCHC-type containing 5, SIRH9, retrotransposon Gag like 3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 2685221 HomoloGene: 19397 GeneCards: RTL3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
Retrotransposon Gag like 3 is a protein that in humans is encoded by the RTL3 gene. [5]
Function
This gene is a member of a family of gag-related retrotransposon genes. These genes appear to have lost the ability to retrotranspose; however, their open reading frames have remained intact, which may indicate that these genes have acquired new functions in the cell. Retrotransposon gag-like-3 (RTL3/ZCCHC5/MART3) is one of eleven Sushi-like neogenes identified in the human genome7 RTL3 encodes a 53 kDa protein with a nucleic acid-binding domain (CX2CX4HX4C), gag-like region within the open reading frame and an ssDNA/RNA-binding homeobox-associated leucine zipper motif.[6] It has been reported that RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000179300 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047686 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Retrotransposon Gag like 3". Retrieved 2017-09-18.
- ^ a b Ball HC, Ansari MY, Ahmad N, Novak K, Haqqi TM (November 2021). "A retrotransposon gag-like-3 gene RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes". Connective Tissue Research. 62 (6): 615–628. doi:10.1080/03008207.2020.1828380. PMC 8404968. PMID 33043724.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 | This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it. |