SLC22A13

SLC22A13
Identifiers
Aliases	SLC22A13, OAT10, OCTL1, OCTL3, ORCTL-3, ORCTL3, solute carrier family 22 member 13
External IDs	OMIM: 604047 MGI: 2143107 HomoloGene: 3140 GeneCards: SLC22A13
Gene location (Human)
Chr.	Chromosome 3 (human)
End	38,278,757 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	119,038,164 bp
RNA expression pattern
	Top expressed in
	kidney; ; renal cortex; ; stromal cell of endometrium; ; metanephros; ; blood; ; cerebellum; ; cerebellar cortex; ; gastrocnemius muscle; ; cerebellar hemisphere; ; prefrontal cortex;
	Top expressed in
	kidney; ; proximal tubule; ; proximal straight tubule; ; morula; ; thyroid gland; ; proximal convoluted tubule; ; Greater petrosal nerve; ; right ventricle; ; ascending aorta; ; jejunum;
	More reference expression data
	n/a
Gene ontology
Molecular function	transmembrane transporter activity; organic cation transmembrane transporter activity; nicotinate transmembrane transporter activity; inorganic anion exchanger activity; sodium-independent organic anion transmembrane transporter activity;
Cellular component	integral component of plasma membrane; apical plasma membrane; membrane; extracellular exosome; integral component of membrane; plasma membrane;
Biological process	nicotinate transport; transmembrane transport; urate transport; organic cation transport; NAD biosynthesis via nicotinamide riboside salvage pathway; inorganic anion transport; sodium-independent organic anion transport;
	Sources:Amigo / QuickGO
Orthologs
	9390
	102570
	ENSG00000172940
	ENSMUSG00000074028
	Q9Y226
	Q6A4L0
	NM_004256
	NM_133980
	NP_004247
	NP_598741
	Wikidata
View/Edit Human	View/Edit Mouse

The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.

Solute carrier family 22 member 13 is a protein that in humans is encoded by the SLC22A13 gene. ^[5]

Function

This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to mediate urate uptake and is a high affinity nicotinate exchanger in the kidneys and the intestine.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172940 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074028 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Solute carrier family 22 member 13". Retrieved 2017-10-05.

Bahn A, Hagos Y, Reuter S, Balen D, Brzica H, Krick W, Burckhardt BC, Sabolic I, Burckhardt G (2008). "Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13)". J. Biol. Chem. 283 (24): 16332–41. doi:10.1074/jbc.M800737200. PMID 18411268.
Irshad S, Mahul-Mellier AL, Kassouf N, Lemarie A, Grimm S (2009). "Isolation of ORCTL3 in a novel genetic screen for tumor-specific apoptosis inducers". Cell Death Differ. 16 (6): 890–8. doi:10.1038/cdd.2009.21. PMC 2683172. PMID 19282870.
Tzvetkov MV, Vormfelde SV, Balen D, Meineke I, Schmidt T, Sehrt D, Sabolić I, Koepsell H, Brockmöller J (2009). "The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin". Clin. Pharmacol. Ther. 86 (3): 299–306. doi:10.1038/clpt.2009.92. PMID 19536068. S2CID 8583867.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Schulz C, Fork C, Bauer T, Golz S, Geerts A, Schömig E, Gründemann D (2014). "SLC22A13 catalyses unidirectional efflux of aspartate and glutamate at the basolateral membrane of type A intercalated cells in the renal collecting duct". Biochem. J. 457 (2): 243–51. doi:10.1042/BJ20130654. PMID 24147638.
AbuAli G, Chaisaklert W, Stelloo E, Pazarentzos E, Hwang MS, Qize D, Harding SV, Al-Rubaish A, Alzahrani AJ, Al-Ali A, Sanders TA, Aboagye EO, Grimm S (2015). "The anticancer gene ORCTL3 targets stearoyl-CoA desaturase-1 for tumour-specific apoptosis". Oncogene. 34 (13): 1718–28. doi:10.1038/onc.2014.93. PMC 4119473. PMID 24769897.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172940 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074028 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Solute carrier family 22 member 13". Retrieved 2017-10-05.

[1]

[2]

[3]

[4]

[5]

Function

References

Further reading