Shoukhrat Mitalipov: Difference between revisions
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{{Short description|Kazakh-American microbiologist (born 1961)}} |
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'''Shoukhrat Mitalipov''' ({{respell|Shoe|KHRAHT|_|Mee|tuhl|EE|pov}}, {{lang-ru|Шухрат Музапарович Миталипов}};<ref>[https://tengrinews.kz/science/uchenyiy-kazahstana-pervyiy-mire-sozdal-obezyanu-mutanta-205270/ Ученый из Казахстана первый в мире создал обезьяну-мутанта – новости науки | Tengrinews] {{in lang|ru}}</ref> born 1961)<ref name=Ire>{{cite news |url= https://www.nytimes.com/2014/03/18/science/shoukhrat-mitalipovs-mitochrondrial-manipulations.html?_r=0 |title= His Fertility Advance Draws Ire |date= March 17, 2014 |last= Tavernise |first= Sabrina |newspaper= [[The New York Times]] |accessdate= March 4, 2015}}</ref> is an American biologist who heads the Center for Embryonic Cell and Gene Therapy at the [[Oregon Health & Science University]] in [[Portland, Oregon|Portland]].<ref name=Splice>{{cite news |url= http://www.wweek.com/portland/article-23100-splice_of_life.html |title= Splice of Life |last= Moore |first= Elizabeth Armstrong |date= September 17, 2014 |newspaper= [[Willamette Week]] |page= 12 |accessdate= March 4, 2015}}</ref> He is a well known pioneer of many nuclear transplantation studies and was named in 2013 by journal ''Nature'' as "the cloning chief".{{citation needed|date=January 2020}} Mitalipov is also a godfather of a gene therapy, known as mitochondrial replacement therapy, that prevents inheritance of mitochondrial diseases. He discovered a new way of creating human [[stem cells]] from skin cells.<ref name=Splice/><ref name=About>{{cite web |url= http://www.ohsu.edu/xd/research/centers-institutes/embryonic-cell-gene-therapy-center/about.cfm |title= About Us |publisher= Center for Embryonic Cell and Gene Therapy |accessdate= March 4, 2015}}</ref> |
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{{Infobox scientist |
{{Infobox scientist |
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| birth_place = [[Almaty]], Kazakh SSR, [[USSR]] |
| birth_place = [[Almaty]], Kazakh SSR, [[USSR]] |
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| citizenship = American |
| citizenship = American |
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| nationality = |
| nationality = Kazakhstani |
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| workplaces = [[Utah State University]], [[Oregon Health and Science University]] |
| workplaces = [[Utah State University]], [[Oregon Health and Science University]] |
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| alma_mater = [[Timiryazev Agricultural Academy]] Research Centre of Medical Genetics |
| alma_mater = [[Timiryazev Agricultural Academy]] Research Centre of Medical Genetics |
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In May 2013, Mitalipov and his team published a study in ''[[Cell (journal)|Cell]]'' that describes a new process for creating human stem cells from skin cells.<ref name=About/> The stem cell discovery made several journals' "Top 10" scientific breakthrough lists in 2013, including ''[[Nature (journal)|Nature]]'', ''[[Science (magazine)|Science]]'', ''[[Time (magazine)|Time]]'', ''[[Discover (magazine)|Discover]]'', ''[[National Geographic (magazine)|National Geographic]]'' and ''[[The Week]]''.<ref name=About/> |
In May 2013, Mitalipov and his team published a study in ''[[Cell (journal)|Cell]]'' that describes a new process for creating human stem cells from skin cells.<ref name=About/> The stem cell discovery made several journals' "Top 10" scientific breakthrough lists in 2013, including ''[[Nature (journal)|Nature]]'', ''[[Science (magazine)|Science]]'', ''[[Time (magazine)|Time]]'', ''[[Discover (magazine)|Discover]]'', ''[[National Geographic (magazine)|National Geographic]]'' and ''[[The Week]]''.<ref name=About/> |
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In August 2017, Mitalipov's collaborative work with the [[Institute for Basic Science]], [[Salk Institute for Biological Studies]], [[Seoul National University]], [[BGI-Shenzhen]] and BGI-Qingdao, was published in ''[[Nature (journal)|Nature]]''.<ref>{{cite journal | doi = 10.1038/nature23305 | volume=548 | title=Correction of a pathogenic gene mutation in human embryos | year=2017 | journal=Nature | pages=413–419 | last1 = Ma | first1 = Hong | last2 = Marti-Gutierrez | first2 = Nuria | last3 = Park | first3 = Sang-Wook | last4 = Wu | first4 = Jun | last5 = Lee | first5 = Yeonmi | last6 = Suzuki | first6 = Keiichiro | last7 = Koski | first7 = Amy | last8 = Ji | first8 = Dongmei | last9 = Hayama | first9 = Tomonari | last10 = Ahmed | first10 = Riffat | last11 = Darby | first11 = Hayley | last12 = Van Dyken | first12 = Crystal | last13 = Li | first13 = Ying | last14 = Kang | first14 = Eunju | last15 = Park | first15 = A.-Reum | last16 = Kim | first16 = Daesik | last17 = Kim | first17 = Sang-Tae | last18 = Gong | first18 = Jianhui | last19 = Gu | first19 = Ying | last20 = Xu | first20 = Xun | last21 = Battaglia | first21 = David | last22 = Krieg | first22 = Sacha A. | last23 = Lee | first23 = David M. | last24 = Wu | first24 = Diana H. | last25 = Wolf | first25 = Don P. | last26 = Heitner | first26 = Stephen B. | last27 = Carlos Izpisua Belmonte | first27 = Juan | last28 = Amato | first28 = Paula | last29 = Kim | first29 = Jin-Soo | last30 = Kaul | first30 = Sanjiv | last31 = Mitalipov | first31 = Shoukhrat | pmid=28783728| doi-access = free }}</ref> performed the first known successful attempt at genetically correcting mutant human embryos, using the [[CRISPR]]/Cas9 gene modifying tool. |
In August 2017, Mitalipov's collaborative work with the [[Institute for Basic Science]], [[Salk Institute for Biological Studies]], [[Seoul National University]], [[BGI-Shenzhen]] and BGI-Qingdao, was published in ''[[Nature (journal)|Nature]]''.<ref>{{cite journal | doi = 10.1038/nature23305 | volume=548 | title=Correction of a pathogenic gene mutation in human embryos | year=2017 | journal=Nature | pages=413–419 | last1 = Ma | first1 = Hong | last2 = Marti-Gutierrez | first2 = Nuria | last3 = Park | first3 = Sang-Wook | last4 = Wu | first4 = Jun | last5 = Lee | first5 = Yeonmi | last6 = Suzuki | first6 = Keiichiro | last7 = Koski | first7 = Amy | last8 = Ji | first8 = Dongmei | last9 = Hayama | first9 = Tomonari | last10 = Ahmed | first10 = Riffat | last11 = Darby | first11 = Hayley | last12 = Van Dyken | first12 = Crystal | last13 = Li | first13 = Ying | last14 = Kang | first14 = Eunju | last15 = Park | first15 = A.-Reum | last16 = Kim | first16 = Daesik | last17 = Kim | first17 = Sang-Tae | last18 = Gong | first18 = Jianhui | last19 = Gu | first19 = Ying | last20 = Xu | first20 = Xun | last21 = Battaglia | first21 = David | last22 = Krieg | first22 = Sacha A. | last23 = Lee | first23 = David M. | last24 = Wu | first24 = Diana H. | last25 = Wolf | first25 = Don P. | last26 = Heitner | first26 = Stephen B. | last27 = Carlos Izpisua Belmonte | first27 = Juan | last28 = Amato | first28 = Paula | last29 = Kim | first29 = Jin-Soo | last30 = Kaul | first30 = Sanjiv | last31 = Mitalipov | first31 = Shoukhrat | issue=7668 | pmid=28783728| doi-access = free }}</ref> performed the first known successful attempt at genetically correcting mutant human embryos, using the [[CRISPR]]/Cas9 gene modifying tool. |
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Mitalipov and his team experimented upon a larger number of human embryos carrying a genetic defect causing heart disease. They demonstrated the possibility of safely and efficiently correcting the defective gene that cause inherited heart disease.<ref>{{Cite web|url=https://www.technologyreview.com/s/608350/first-human-embryos-edited-in-us/|title=First human embryos edited in U.S., using CRISPR|last=Connor|first=Steve|website=MIT Technology Review|language=en|access-date=2019-02-17}}</ref> |
Mitalipov and his team experimented upon a larger number of human embryos carrying a genetic defect causing heart disease. They demonstrated the possibility of safely and efficiently correcting the defective gene that cause inherited heart disease.<ref>{{Cite web|url=https://www.technologyreview.com/s/608350/first-human-embryos-edited-in-us/|title=First human embryos edited in U.S., using CRISPR|last=Connor|first=Steve|website=MIT Technology Review|language=en|access-date=2019-02-17}}</ref> |
Revision as of 23:47, 30 July 2023
Shoukhrat Mitalipov (Shoe-KHRAHT Mee-tuhl-EE-pov, Russian: Шухрат Музапарович Миталипов;[1] born 1961)[2] is an American biologist who heads the Center for Embryonic Cell and Gene Therapy at the Oregon Health & Science University in Portland.[3] He is a well known pioneer of many nuclear transplantation studies and was named in 2013 by journal Nature as "the cloning chief".[citation needed] Mitalipov is also a godfather of a gene therapy, known as mitochondrial replacement therapy, that prevents inheritance of mitochondrial diseases. He discovered a new way of creating human stem cells from skin cells.[3][4]
Shoukhrat Mitalipov | |
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Born | 1961 |
Nationality | Kazakhstani |
Citizenship | American |
Alma mater | Timiryazev Agricultural Academy Research Centre of Medical Genetics |
Scientific career | |
Institutions | Utah State University, Oregon Health and Science University |
Doctoral students | Nuria Martí Gutiérrez |
Early life
Mitalipov was born in 1961 in Almaty, Kazakhstan, then part of the Soviet Union.[3] He is of Uyghur ancestry.[5] He served two years in Soviet military, beginning in 1979, as an army radio technician.[5]
Education
After the military, Mitalipov studied genetics at the Timiryazev Agricultural Academy in Moscow and also played blues guitar in a cover band to pay the bills.[3] After his graduation from the academy, he worked for a short time as the chief livestock specialist in a kolkhoz in the Yaroslavl region.[6] He received his master's degree in 1989.[3] He earned his PhD in developmental and stem cell biology from the Research Centre of Medical Genetics in Moscow.[3] After the fall of the Soviet Union in 1991 funding for stem cell research was scarce, so Mitalipov applied for and won a fellowship at Utah State University in 1995.[3] He started working at the Oregon National Primate Research Center in 1998, where he could work with monkeys, which share 98% of their DNA with humans; at Utah State Mitalipov had worked with cow DNA.[3]
Breakthroughs
A therapy for mitochondrial diseases that Mitalipov discovered, the "spindle transfer" technique, involves removing the nucleus from a human egg and placing it into another.[2][3] If the egg is fertilized, in genetic terms it would have three parents.[3] Mitalipov has successfully bred "three-parent" rhesus macaques.[3] The possibility of using the procedure on human eggs has raised safety and ethics questions.[3]
In May 2013, Mitalipov and his team published a study in Cell that describes a new process for creating human stem cells from skin cells.[4] The stem cell discovery made several journals' "Top 10" scientific breakthrough lists in 2013, including Nature, Science, Time, Discover, National Geographic and The Week.[4]
In August 2017, Mitalipov's collaborative work with the Institute for Basic Science, Salk Institute for Biological Studies, Seoul National University, BGI-Shenzhen and BGI-Qingdao, was published in Nature.[7] performed the first known successful attempt at genetically correcting mutant human embryos, using the CRISPR/Cas9 gene modifying tool.
Mitalipov and his team experimented upon a larger number of human embryos carrying a genetic defect causing heart disease. They demonstrated the possibility of safely and efficiently correcting the defective gene that cause inherited heart disease.[8]
Honors and awards
- 1995 – Fellowship award, Exchange Visitor Program "Cooperation in Applied Sciences and Technologies (CAST)". Development of culture system to maintain pluripotency of bovine embryonic stem cells. Utah State University.
- 2010 – Recipient of the 2010 Discovery Award, The Medical Research Foundation of Oregon
- 2010 – Recipient of 2010 Women's Health Research Award, the Center for Women's Health, Circle of Giving
- 2013 – Recognized by journal Nature as top 10 people who mattered in 2013
- 2017 – Recipient of "Thousand Talents Plan" Award in China in the category of the Recruitment Program for Foreign Experts[9]
Salient publications
- Tachibana, Masahito; Sparman, Michelle; Sritanaudomchai, Hathaitip; Ma, Hong; Clepper, Lisa; Woodward, Joy; Li, Ying; Ramsey, Cathy; Kolotushkina, Olena; Mitalipov, Shoukhrat (2009). "Mitochondrial gene replacement in primate offspring and embryonic stem cells". Nature. 461 (7262). Nature Portfolio: 367–372. doi:10.1038/nature08368. ISSN 0028-0836. PMC 2774772. PMID 19710649. S2CID 1203203. NIHMSID 137913.
- — Widely cited including by:
- Mishra, Prashant; Chan, David (2014). "Mitochondrial dynamics and inheritance during cell division, development and disease". Nature Reviews Molecular Cell Biology. 15 (10). Nature Portfolio: 634–646. doi:10.1038/nrm3877. ISSN 1471-0072. PMC 4250044. PMID 25237825. S2CID 18105759. NIHMSID 644044.
See also
References
- ^ Ученый из Казахстана первый в мире создал обезьяну-мутанта – новости науки | Tengrinews (in Russian)
- ^ a b Tavernise, Sabrina (March 17, 2014). "His Fertility Advance Draws Ire". The New York Times. Retrieved March 4, 2015.
- ^ a b c d e f g h i j k l Moore, Elizabeth Armstrong (September 17, 2014). "Splice of Life". Willamette Week. p. 12. Retrieved March 4, 2015.
- ^ a b c "About Us". Center for Embryonic Cell and Gene Therapy. Retrieved March 4, 2015.
- ^ a b Budnick, Nick (June 2, 2013). "Oregon Stem-cell Groundbreaker Stirs International Frenzy with Cloning Advance". The Oregonian. Retrieved March 4, 2015.
- ^ Астахова, Алла (August 12, 2017). "Тонкая работа". Блог о здравоохранении (in Russian).
- ^ Ma, Hong; Marti-Gutierrez, Nuria; Park, Sang-Wook; Wu, Jun; Lee, Yeonmi; Suzuki, Keiichiro; Koski, Amy; Ji, Dongmei; Hayama, Tomonari; Ahmed, Riffat; Darby, Hayley; Van Dyken, Crystal; Li, Ying; Kang, Eunju; Park, A.-Reum; Kim, Daesik; Kim, Sang-Tae; Gong, Jianhui; Gu, Ying; Xu, Xun; Battaglia, David; Krieg, Sacha A.; Lee, David M.; Wu, Diana H.; Wolf, Don P.; Heitner, Stephen B.; Carlos Izpisua Belmonte, Juan; Amato, Paula; Kim, Jin-Soo; Kaul, Sanjiv; Mitalipov, Shoukhrat (2017). "Correction of a pathogenic gene mutation in human embryos". Nature. 548 (7668): 413–419. doi:10.1038/nature23305. PMID 28783728.
- ^ Connor, Steve. "First human embryos edited in U.S., using CRISPR". MIT Technology Review. Retrieved February 17, 2019.
- ^ People, Oregon Health & Science University. "Shoukhrat Mitalipov, PhD | OHSU People". Oregon Health & Science University. Retrieved March 25, 2019.