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{{Short description|Kazakh-American microbiologist (born 1961)}}
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{{Infobox person
{{Use American English|date = February 2019}}
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|name = Shoukhrat Mitalipov
{{Use mdy dates|date = February 2019}}
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|birth_date = {{birth year and age|1961}}
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'''Shoukhrat Mitalipov''' ({{respell|Shoe|KHRAHT|_|Mee|tuhl|EE|pov}}, {{lang-ru|Шухрат Музапарович Миталипов}};<ref>[https://tengrinews.kz/science/uchenyiy-kazahstana-pervyiy-mire-sozdal-obezyanu-mutanta-205270/ Ученый из Казахстана первый в мире создал обезьяну-мутанта – новости науки | Tengrinews] {{in lang|ru}}</ref> born 1961)<ref name=Ire>{{cite news |url= https://www.nytimes.com/2014/03/18/science/shoukhrat-mitalipovs-mitochrondrial-manipulations.html?_r=0 |title= His Fertility Advance Draws Ire |date= March 17, 2014 |last= Tavernise |first= Sabrina |newspaper= [[The New York Times]] |accessdate= March 4, 2015}}</ref> is an American biologist who heads the Center for Embryonic Cell and Gene Therapy at the [[Oregon Health & Science University]] in [[Portland, Oregon|Portland]].<ref name=Splice>{{cite news |url= http://www.wweek.com/portland/article-23100-splice_of_life.html |title= Splice of Life |last= Moore |first= Elizabeth Armstrong |date= September 17, 2014 |newspaper= [[Willamette Week]] |page= 12 |accessdate= March 4, 2015}}</ref> He is a well known pioneer of many nuclear transplantation studies and was named in 2013 by journal ''Nature'' as "the cloning chief".{{citation needed|date=January 2020}} Mitalipov is also a godfather of a gene therapy, known as mitochondrial replacement therapy, that prevents inheritance of mitochondrial diseases. He discovered a new way of creating human [[stem cells]] from skin cells.<ref name=Splice/><ref name=About>{{cite web |url= http://www.ohsu.edu/xd/research/centers-institutes/embryonic-cell-gene-therapy-center/about.cfm |title= About Us |publisher= Center for Embryonic Cell and Gene Therapy |accessdate= March 4, 2015}}</ref>
|occupation = Scientist

|image =
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{{Infobox scientist
|citizenship = American<ref name=Frenzy/>
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| name = Shoukhrat Mitalipov
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|alma_mater = [[Timiryazev Agricultural Academy]]<br>[[Research Centre of Medical Genetics]]
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| birth_date = 1961
|known_for = [[Stem cell]] breakthrough
| birth_place = [[Almaty]], Kazakh SSR, [[USSR]]
| citizenship = American
| nationality = Kazakhstani
| workplaces = [[Utah State University]], [[Oregon Health and Science University]]
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| alma_mater = [[Timiryazev Agricultural Academy]] Research Centre of Medical Genetics
| doctoral_students = [[Nuria Martí Gutiérrez]]
}}
}}
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'''Shoukhrat Mitalipov''' (Shoe-KHRAHT Mee-tuhl-EE-pov, {{lang-ru|Шухрат Музапарович Миталипов}},<ref>[https://tengrinews.kz/science/uchenyiy-kazahstana-pervyiy-mire-sozdal-obezyanu-mutanta-205270/ Ученый из Казахстана первый в мире создал обезьяну-мутанта - новости науки | Tengrinews] {{ru icon}}</ref> born 1961)<ref name=Ire>{{cite news |url= https://www.nytimes.com/2014/03/18/science/shoukhrat-mitalipovs-mitochrondrial-manipulations.html?_r=0 |title= His Fertility Advance Draws Ire |date= March 17, 2014 |last= Tavernise |first= Sabrina |newspaper= [[The New York Times]] |accessdate= March 4, 2015}}</ref> is an American biologist who heads the Center for Embryonic Cell and Gene Therapy at the [[Oregon Health & Science University]] in [[Portland, Oregon|Portland]].<ref name=Splice>{{cite news |url= http://www.wweek.com/portland/article-23100-splice_of_life.html |title= Splice of Life |last= Moore |first= Elizabeth Armstrong |date= September 17, 2014 |newspaper= [[Willamette Week]] |page= 12 |accessdate= March 4, 2015}}</ref> He is known for discovering a controversial genetic therapy that may be a way to prevent [[mitochondrial disease]]s, as well as a new way of creating human [[stem cells]] from skin cells.<ref name=Splice/><ref name=About>{{cite web |url= http://www.ohsu.edu/xd/research/centers-institutes/embryonic-cell-gene-therapy-center/about.cfm |title= About Us |publisher= Center for Embryonic Cell and Gene Therapy |accessdate= March 4, 2015}}</ref>


==Early life==
==Early life==
Mitalipov was born in 1961 in [[Almaty]], [[Kazakhstan]], then part of the [[Soviet Union]].<ref name=Splice/> He is of [[Uyghur people|Uyghur]] ancestry.<ref name=Frenzy>{{cite news |url= http://www.oregonlive.com/health/index.ssf/2013/06/oregon_stem-cell_groundbreaker.html |title= Oregon Stem-cell Groundbreaker Stirs International Frenzy with Cloning Advance |date= June 2, 2013 |last= Budnick |first= Nick |newspaper= [[The Oregonian]] |accessdate= March 4, 2015}}</ref> He served two years in Soviet military, beginning in 1979, as an army radio technician.<ref name=Frenzy/>
Mitalipov was born in 1961 in [[Almaty]], [[Kazakhstan]], then part of the [[Soviet Union]].<ref name=Splice/> He is of [[Uyghurs|Uyghur]] ancestry.<ref name=Frenzy>{{cite news |url= http://www.oregonlive.com/health/index.ssf/2013/06/oregon_stem-cell_groundbreaker.html |title= Oregon Stem-cell Groundbreaker Stirs International Frenzy with Cloning Advance |date= June 2, 2013 |last= Budnick |first= Nick |newspaper= [[The Oregonian]] |accessdate= March 4, 2015}}</ref> He served two years in [[Soviet Armed Forces|Soviet military]], beginning in 1979, as an army radio technician.<ref name=Frenzy/>


==Education==
==Education==
After the military, Mitalipov studied genetics at the [[Timiryazev Agricultural Academy]] in [[Moscow]], and also played blues guitar in a cover band to pay the bills.<ref name=Splice/> After graduation from the academy, he worked for a short time as the chief livestock specialist in the kolkhoz in the Yaroslavl region.<ref>{{Cite web|url=http://alla-astakhova.ru/tonkaya-rabota/|title=Тонкая работа|last=Астахова|first=Алла|date=12 August 2017|website=Блог о здравоохранении|archive-url=|archive-date=|dead-url=|accessdate=}}</ref> He received his [[master's degree]] in 1989.<ref name=Splice/> He earned his [[Ph.D.]] in developmental and stem cell biology from the [[Research Centre of Medical Genetics]] in Moscow.<ref name=Splice/> After the [[fall of the Soviet Union]] in 1991 funding for stem cell research was scarce, so Mitalipov applied for and won a fellowship at [[Utah State University]] in 1995.<ref name=Splice/> He started working at the [[Oregon National Primate Research Center]] in 1998, where he could work with monkeys, which share 98% of their DNA with humans; at Utah State Mitalipov had worked with cow DNA.<ref name=Splice/>
After the military, Mitalipov studied genetics at the [[Timiryazev Agricultural Academy]] in [[Moscow]] and also played blues guitar in a cover band to pay the bills.<ref name=Splice/> After his graduation from the academy, he worked for a short time as the chief livestock specialist in a [[kolkhoz]] in the Yaroslavl region.<ref>{{Cite web|url=http://alla-astakhova.ru/tonkaya-rabota/|title=Тонкая работа|last=Астахова|first=Алла|date=12 August 2017|website=Блог о здравоохранении|language=Russian}}</ref> He received his [[master's degree]] in 1989.<ref name=Splice/> He earned his [[PhD]] in developmental and stem cell biology from the Research Centre of Medical Genetics in Moscow.<ref name=Splice/> After the [[fall of the Soviet Union]] in 1991 funding for stem cell research was scarce, so Mitalipov applied for and won a fellowship at [[Utah State University]] in 1995.<ref name=Splice/> He started working at the [[Oregon National Primate Research Center]] in 1998, where he could work with monkeys, which share 98% of their DNA with humans; at Utah State Mitalipov had worked with cow DNA.<ref name=Splice/>


==Breakthroughs==
==Breakthroughs==
A therapy for [[mitochondrial disease]]s that Mitalipov discovered, the "[[spindle transfer]]" technique, involves removing the nucleus from a human egg and placing it into another.<ref name=Ire/><ref name=Splice/> If the egg is fertilized, in genetic terms it would have three parents.<ref name=Splice/> Mitalipov has successfully bred "[[Three-parent baby|three-parent]]" [[rhesus macaque]]s.<ref name=Splice/> The possibility of using the procedure on human eggs has raised safety and ethics questions.<ref name=Splice/>
A therapy for [[mitochondrial disease]]s that Mitalipov discovered, the "[[spindle transfer]]" technique, involves removing the nucleus from a human egg and placing it into another.<ref name=Ire/><ref name=Splice/> If the egg is fertilized, in genetic terms it would have three parents.<ref name=Splice/> Mitalipov has successfully bred "[[Three-parent baby|three-parent]]" [[rhesus macaque]]s.<ref name=Splice/> The possibility of using the procedure on human eggs has raised safety and ethics questions.<ref name=Splice/>


In May 2013, Mitalipov and his team published a study in ''[[Cell (journal)|Cell]]'' that describes a new process for creating human stem cells from skin cells.<ref name=About/> The stem cell discovery made several journals' "Top 10" scientific breakthrough lists in 2013, including ''[[Nature (journal)|Nature]]'', ''[[Science (magazine)|Science]]'', ''[[Time (magazine)|Time]]'', ''[[Discover (magazine)|Discover]]'', ''[[National Geographic (magazine)|National Geographic]]'', and ''[[The Week]]''.<ref name=About/>
In May 2013, Mitalipov and his team published a study in ''[[Cell (journal)|Cell]]'' that describes a new process for creating human stem cells from skin cells.<ref name=About/> The stem cell discovery made several journals' "Top 10" scientific breakthrough lists in 2013, including ''[[Nature (journal)|Nature]]'', ''[[Science (magazine)|Science]]'', ''[[Time (magazine)|Time]]'', ''[[Discover (magazine)|Discover]]'', ''[[National Geographic (magazine)|National Geographic]]'' and ''[[The Week]]''.<ref name=About/>


In August 2017, Mitalipov's collaborative work with the [[Institute for Basic Science]], [[Salk Institute for Biological Studies]], [[Seoul National University]], [[BGI-Shenzhen]], and BGI-Qingdao, is published in [[Nature (journal)|Nature]].<ref>{{cite journal | doi = 10.1038/nature23305 | volume=548 | title=Correction of a pathogenic gene mutation in human embryos | year=2017 | journal=Nature | pages=413–419 | last1 = Ma | first1 = Hong | last2 = Marti-Gutierrez | first2 = Nuria | last3 = Park | first3 = Sang-Wook | last4 = Wu | first4 = Jun | last5 = Lee | first5 = Yeonmi | last6 = Suzuki | first6 = Keiichiro | last7 = Koski | first7 = Amy | last8 = Ji | first8 = Dongmei | last9 = Hayama | first9 = Tomonari | last10 = Ahmed | first10 = Riffat | last11 = Darby | first11 = Hayley | last12 = Van Dyken | first12 = Crystal | last13 = Li | first13 = Ying | last14 = Kang | first14 = Eunju | last15 = Park | first15 = A.-Reum | last16 = Kim | first16 = Daesik | last17 = Kim | first17 = Sang-Tae | last18 = Gong | first18 = Jianhui | last19 = Gu | first19 = Ying | last20 = Xu | first20 = Xun | last21 = Battaglia | first21 = David | last22 = Krieg | first22 = Sacha A. | last23 = Lee | first23 = David M. | last24 = Wu | first24 = Diana H. | last25 = Wolf | first25 = Don P. | last26 = Heitner | first26 = Stephen B. | last27 = Carlos Izpisua Belmonte | first27 = Juan | last28 = Amato | first28 = Paula | last29 = Kim | first29 = Jin-Soo | last30 = Kaul | first30 = Sanjiv | last31 = Mitalipov | first31 = Shoukhrat}}</ref> performed the first known successful attempt at genetically correcting mutant human embryos, using the [[CRISPR|CRISPR/Cas9]] gene modifying tool.
In August 2017, Mitalipov's collaborative work with the [[Institute for Basic Science]], [[Salk Institute for Biological Studies]], [[Seoul National University]], [[BGI-Shenzhen]] and BGI-Qingdao, was published in ''[[Nature (journal)|Nature]]''.<ref>{{cite journal | doi = 10.1038/nature23305 | volume=548 | title=Correction of a pathogenic gene mutation in human embryos | year=2017 | journal=Nature | pages=413–419 | last1 = Ma | first1 = Hong | last2 = Marti-Gutierrez | first2 = Nuria | last3 = Park | first3 = Sang-Wook | last4 = Wu | first4 = Jun | last5 = Lee | first5 = Yeonmi | last6 = Suzuki | first6 = Keiichiro | last7 = Koski | first7 = Amy | last8 = Ji | first8 = Dongmei | last9 = Hayama | first9 = Tomonari | last10 = Ahmed | first10 = Riffat | last11 = Darby | first11 = Hayley | last12 = Van Dyken | first12 = Crystal | last13 = Li | first13 = Ying | last14 = Kang | first14 = Eunju | last15 = Park | first15 = A.-Reum | last16 = Kim | first16 = Daesik | last17 = Kim | first17 = Sang-Tae | last18 = Gong | first18 = Jianhui | last19 = Gu | first19 = Ying | last20 = Xu | first20 = Xun | last21 = Battaglia | first21 = David | last22 = Krieg | first22 = Sacha A. | last23 = Lee | first23 = David M. | last24 = Wu | first24 = Diana H. | last25 = Wolf | first25 = Don P. | last26 = Heitner | first26 = Stephen B. | last27 = Carlos Izpisua Belmonte | first27 = Juan | last28 = Amato | first28 = Paula | last29 = Kim | first29 = Jin-Soo | last30 = Kaul | first30 = Sanjiv | last31 = Mitalipov | first31 = Shoukhrat | issue=7668 | pmid=28783728| doi-access = free }}</ref> performed the first known successful attempt at genetically correcting mutant human embryos, using the [[CRISPR]]/Cas9 gene modifying tool.


Mitalipov and his team experimented upon a larger number of human embryos carrying a genetic defect causing heart disease. They demonstrated the possibility of safely and efficiently correcting the defective gene that cause inherited heart disease.<ref>https://www.technologyreview.com/s/608350/first-human-embryos-edited-in-us/?set=608342</ref>
Mitalipov and his team experimented upon a larger number of human embryos carrying a genetic defect causing heart disease. They demonstrated the possibility of safely and efficiently correcting the defective gene that cause inherited heart disease.<ref>{{Cite web|url=https://www.technologyreview.com/s/608350/first-human-embryos-edited-in-us/|title=First human embryos edited in U.S., using CRISPR|last=Connor|first=Steve|website=MIT Technology Review|language=en|access-date=2019-02-17}}</ref>

== Honors and awards ==

* 1995 – Fellowship award, Exchange Visitor Program "Cooperation in Applied Sciences and Technologies (CAST)". Development of culture system to maintain pluripotency of bovine embryonic stem cells. Utah State University.
* 2010 – Recipient of the 2010 Discovery Award, The Medical Research Foundation of Oregon
* 2010 – Recipient of 2010 Women's Health Research Award, the [[Oregon Health and Science University Center for Women's Health|Center for Women's Health]], Circle of Giving
* 2013 – Recognized by journal [[Nature (journal)|Nature]] as top 10 people who mattered in 2013
* 2017 – Recipient of "[[Thousand Talents Program (China)|Thousand Talents Plan]]" Award in China in the category of the Recruitment Program for Foreign Experts<ref>{{Cite web|url=http://www.ohsu.edu/xd/about/index.cfm?sAddToHeader=&sPageStyle=Interior%20Full%20Width&sPromotedParentLabel=&sHorizontalJSONNav=&sPromotedParentHeader=&sPageTitle=Shoukhrat%20Mitalipov%2C%20Ph%2ED%2E%20%7C%20OHSU%20People&bIsStandaloneTemplateCall=true|title=Shoukhrat Mitalipov, PhD {{!}} OHSU People|last=People|first=Oregon Health & Science University|website=Oregon Health & Science University|language=en|access-date=2019-03-25}}</ref>

== Salient publications ==
* {{ Cite journal
| year = 2009
| publisher = [[Nature Portfolio]]
| issn = 0028-0836
| journal = [[Nature (journal)|Nature]]
| volume = 461
| issue = 7262
| first8 = Cathy
| first7 = Ying
| first6 = Joy
| first5 = Lisa
| first4 = Hong
| first2 = Michelle
| first9 = Olena
| last7 = Li
| last4 = Ma
| last6 = Woodward
| last8 = Ramsey
| last5 = Clepper
| id = [[NIH Manuscript Submission|NIHMSID]] 137913
| first1 = Masahito
| last2 = Sparman
| last1 = Tachibana
| pages = 367–372
| s2cid = 1203203
| pmid = 19710649
| pmc= 2774772
| first3 = Hathaitip
| last9 = Kolotushkina
| last3 = Sritanaudomchai
| title = Mitochondrial gene replacement in primate offspring and embryonic stem cells
| doi= 10.1038/nature08368
| first10 = Shoukhrat
| last10 = Mitalipov
| author10-link = Shoukhrat Mitalipov
}}
:— Widely cited including by:
::* {{ Cite journal
| year = 2014
| publisher = [[Nature Portfolio]]
| issue = 10
| volume = 15
| journal = [[Nature Reviews Molecular Cell Biology]]
| issn = 1471-0072
| first2 = David
| first1 = Prashant
| last2 = Chan
| last1 = Mishra
| id = [[NIH Manuscript Submission|NIHMSID]] 644044
| pages = 634–646
| s2cid = 18105759
| pmid = 25237825
| pmc = 4250044
| doi = 10.1038/nrm3877
| title = Mitochondrial dynamics and inheritance during cell division, development and disease
}}


==See also==
==See also==
*[[Uyghur Americans]]
*[[Chimera (genetics)]]
*[[Chimera (genetics)]]
*[[Human cloning]]
*[[Human cloning]]
*[[Nuclear transfer]]
*[[Nuclear transfer]]
*[[Germline gene therapy]]


==References==
==References==
Line 36: Line 109:
*[http://www.ohsu.edu/xd/research/centers-institutes/onprc/scientific-discovery/scientists/mitalipov.cfm Shoukhrat Mitalipov] at the [[Oregon National Primate Research Center]]
*[http://www.ohsu.edu/xd/research/centers-institutes/onprc/scientific-discovery/scientists/mitalipov.cfm Shoukhrat Mitalipov] at the [[Oregon National Primate Research Center]]
*[http://www.ohsu.edu/xd/research/centers-institutes/embryonic-cell-gene-therapy-center/ Center for Embryonic Cell and Gene Therapy]
*[http://www.ohsu.edu/xd/research/centers-institutes/embryonic-cell-gene-therapy-center/ Center for Embryonic Cell and Gene Therapy]

{{authority control}}


{{DEFAULTSORT:Mitalipov, Shoukhrat}}
{{DEFAULTSORT:Mitalipov, Shoukhrat}}
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[[Category:American people of Kazakhstani descent]]
[[Category:American people of Kazakhstani descent]]
[[Category:American people of Uyghur descent]]
[[Category:American people of Uyghur descent]]
[[Category:American biologists]]
[[Category:21st-century American biologists]]
[[Category:People from Almaty]]
[[Category:People from Almaty]]
[[Category:Stem cell researchers]]

Revision as of 23:47, 30 July 2023

Shoukhrat Mitalipov (Shoe-KHRAHT Mee-tuhl-EE-pov, Russian: Шухрат Музапарович Миталипов;[1] born 1961)[2] is an American biologist who heads the Center for Embryonic Cell and Gene Therapy at the Oregon Health & Science University in Portland.[3] He is a well known pioneer of many nuclear transplantation studies and was named in 2013 by journal Nature as "the cloning chief".[citation needed] Mitalipov is also a godfather of a gene therapy, known as mitochondrial replacement therapy, that prevents inheritance of mitochondrial diseases. He discovered a new way of creating human stem cells from skin cells.[3][4]

Shoukhrat Mitalipov
Born1961
Almaty, Kazakh SSR, USSR
NationalityKazakhstani
CitizenshipAmerican
Alma materTimiryazev Agricultural Academy Research Centre of Medical Genetics
Scientific career
InstitutionsUtah State University, Oregon Health and Science University
Doctoral studentsNuria Martí Gutiérrez

Early life

Mitalipov was born in 1961 in Almaty, Kazakhstan, then part of the Soviet Union.[3] He is of Uyghur ancestry.[5] He served two years in Soviet military, beginning in 1979, as an army radio technician.[5]

Education

After the military, Mitalipov studied genetics at the Timiryazev Agricultural Academy in Moscow and also played blues guitar in a cover band to pay the bills.[3] After his graduation from the academy, he worked for a short time as the chief livestock specialist in a kolkhoz in the Yaroslavl region.[6] He received his master's degree in 1989.[3] He earned his PhD in developmental and stem cell biology from the Research Centre of Medical Genetics in Moscow.[3] After the fall of the Soviet Union in 1991 funding for stem cell research was scarce, so Mitalipov applied for and won a fellowship at Utah State University in 1995.[3] He started working at the Oregon National Primate Research Center in 1998, where he could work with monkeys, which share 98% of their DNA with humans; at Utah State Mitalipov had worked with cow DNA.[3]

Breakthroughs

A therapy for mitochondrial diseases that Mitalipov discovered, the "spindle transfer" technique, involves removing the nucleus from a human egg and placing it into another.[2][3] If the egg is fertilized, in genetic terms it would have three parents.[3] Mitalipov has successfully bred "three-parent" rhesus macaques.[3] The possibility of using the procedure on human eggs has raised safety and ethics questions.[3]

In May 2013, Mitalipov and his team published a study in Cell that describes a new process for creating human stem cells from skin cells.[4] The stem cell discovery made several journals' "Top 10" scientific breakthrough lists in 2013, including Nature, Science, Time, Discover, National Geographic and The Week.[4]

In August 2017, Mitalipov's collaborative work with the Institute for Basic Science, Salk Institute for Biological Studies, Seoul National University, BGI-Shenzhen and BGI-Qingdao, was published in Nature.[7] performed the first known successful attempt at genetically correcting mutant human embryos, using the CRISPR/Cas9 gene modifying tool.

Mitalipov and his team experimented upon a larger number of human embryos carrying a genetic defect causing heart disease. They demonstrated the possibility of safely and efficiently correcting the defective gene that cause inherited heart disease.[8]

Honors and awards

  • 1995 – Fellowship award, Exchange Visitor Program "Cooperation in Applied Sciences and Technologies (CAST)". Development of culture system to maintain pluripotency of bovine embryonic stem cells. Utah State University.
  • 2010 – Recipient of the 2010 Discovery Award, The Medical Research Foundation of Oregon
  • 2010 – Recipient of 2010 Women's Health Research Award, the Center for Women's Health, Circle of Giving
  • 2013 – Recognized by journal Nature as top 10 people who mattered in 2013
  • 2017 – Recipient of "Thousand Talents Plan" Award in China in the category of the Recruitment Program for Foreign Experts[9]

Salient publications

  • Tachibana, Masahito; Sparman, Michelle; Sritanaudomchai, Hathaitip; Ma, Hong; Clepper, Lisa; Woodward, Joy; Li, Ying; Ramsey, Cathy; Kolotushkina, Olena; Mitalipov, Shoukhrat (2009). "Mitochondrial gene replacement in primate offspring and embryonic stem cells". Nature. 461 (7262). Nature Portfolio: 367–372. doi:10.1038/nature08368. ISSN 0028-0836. PMC 2774772. PMID 19710649. S2CID 1203203. NIHMSID 137913.
— Widely cited including by:

See also

References

  1. ^ Ученый из Казахстана первый в мире создал обезьяну-мутанта – новости науки | Tengrinews (in Russian)
  2. ^ a b Tavernise, Sabrina (March 17, 2014). "His Fertility Advance Draws Ire". The New York Times. Retrieved March 4, 2015.
  3. ^ a b c d e f g h i j k l Moore, Elizabeth Armstrong (September 17, 2014). "Splice of Life". Willamette Week. p. 12. Retrieved March 4, 2015.
  4. ^ a b c "About Us". Center for Embryonic Cell and Gene Therapy. Retrieved March 4, 2015.
  5. ^ a b Budnick, Nick (June 2, 2013). "Oregon Stem-cell Groundbreaker Stirs International Frenzy with Cloning Advance". The Oregonian. Retrieved March 4, 2015.
  6. ^ Астахова, Алла (August 12, 2017). "Тонкая работа". Блог о здравоохранении (in Russian).
  7. ^ Ma, Hong; Marti-Gutierrez, Nuria; Park, Sang-Wook; Wu, Jun; Lee, Yeonmi; Suzuki, Keiichiro; Koski, Amy; Ji, Dongmei; Hayama, Tomonari; Ahmed, Riffat; Darby, Hayley; Van Dyken, Crystal; Li, Ying; Kang, Eunju; Park, A.-Reum; Kim, Daesik; Kim, Sang-Tae; Gong, Jianhui; Gu, Ying; Xu, Xun; Battaglia, David; Krieg, Sacha A.; Lee, David M.; Wu, Diana H.; Wolf, Don P.; Heitner, Stephen B.; Carlos Izpisua Belmonte, Juan; Amato, Paula; Kim, Jin-Soo; Kaul, Sanjiv; Mitalipov, Shoukhrat (2017). "Correction of a pathogenic gene mutation in human embryos". Nature. 548 (7668): 413–419. doi:10.1038/nature23305. PMID 28783728.
  8. ^ Connor, Steve. "First human embryos edited in U.S., using CRISPR". MIT Technology Review. Retrieved February 17, 2019.
  9. ^ People, Oregon Health & Science University. "Shoukhrat Mitalipov, PhD | OHSU People". Oregon Health & Science University. Retrieved March 25, 2019.

External links

Retrieved from "https://en.wikipedia.org/w/index.php?title=Shoukhrat_Mitalipov&oldid=1167967502"