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'''Shoukhrat Mitalipov''' (Shoe-KHRAHT Mee-tuhl-EE-pov, {{lang-ru|Шухрат Музапарович Миталипов}};<ref>[https://tengrinews.kz/science/uchenyiy-kazahstana-pervyiy-mire-sozdal-obezyanu-mutanta-205270/ Ученый из Казахстана первый в мире создал обезьяну-мутанта – новости науки | Tengrinews] {{in lang|ru}}</ref> born 1961)<ref name=Ire>{{cite news |url= https://www.nytimes.com/2014/03/18/science/shoukhrat-mitalipovs-mitochrondrial-manipulations.html?_r=0 |title= His Fertility Advance Draws Ire |date= March 17, 2014 |last= Tavernise |first= Sabrina |newspaper= [[The New York Times]] |accessdate= March 4, 2015}}</ref> is an American biologist who heads the Center for Embryonic Cell and Gene Therapy at the [[Oregon Health & Science University]] in [[Portland, Oregon|Portland]].<ref name=Splice>{{cite news |url= http://www.wweek.com/portland/article-23100-splice_of_life.html |title= Splice of Life |last= Moore |first= Elizabeth Armstrong |date= September 17, 2014 |newspaper= [[Willamette Week]] |page= 12 |accessdate= March 4, 2015}}</ref> He is a well known pioneer of many nuclear transplantation studies and was named in 2013 by journal ''Nature'' as "the cloning chief".{{fact|date=January 2020}} Mitalipov is also a godfather of a gene therapy, known as mitochondrial replacement therapy, that prevents inheritance of mitochondrial diseases. He discovered a new way of creating human [[stem cells]] from skin cells.<ref name=Splice/><ref name=About>{{cite web |url= http://www.ohsu.edu/xd/research/centers-institutes/embryonic-cell-gene-therapy-center/about.cfm |title= About Us |publisher= Center for Embryonic Cell and Gene Therapy |accessdate= March 4, 2015}}</ref>
'''Shoukhrat Mitalipov''' ({{respell|Shoe|KHRAHT|_|Mee|tuhl|EE|pov}}, {{lang-ru|Шухрат Музапарович Миталипов}};<ref>[https://tengrinews.kz/science/uchenyiy-kazahstana-pervyiy-mire-sozdal-obezyanu-mutanta-205270/ Ученый из Казахстана первый в мире создал обезьяну-мутанта – новости науки | Tengrinews] {{in lang|ru}}</ref> born 1961)<ref name=Ire>{{cite news |url= https://www.nytimes.com/2014/03/18/science/shoukhrat-mitalipovs-mitochrondrial-manipulations.html?_r=0 |title= His Fertility Advance Draws Ire |date= March 17, 2014 |last= Tavernise |first= Sabrina |newspaper= [[The New York Times]] |accessdate= March 4, 2015}}</ref> is an American biologist who heads the Center for Embryonic Cell and Gene Therapy at the [[Oregon Health & Science University]] in [[Portland, Oregon|Portland]].<ref name=Splice>{{cite news |url= http://www.wweek.com/portland/article-23100-splice_of_life.html |title= Splice of Life |last= Moore |first= Elizabeth Armstrong |date= September 17, 2014 |newspaper= [[Willamette Week]] |page= 12 |accessdate= March 4, 2015}}</ref> He is a well known pioneer of many nuclear transplantation studies and was named in 2013 by journal ''Nature'' as "the cloning chief".{{fact|date=January 2020}} Mitalipov is also a godfather of a gene therapy, known as mitochondrial replacement therapy, that prevents inheritance of mitochondrial diseases. He discovered a new way of creating human [[stem cells]] from skin cells.<ref name=Splice/><ref name=About>{{cite web |url= http://www.ohsu.edu/xd/research/centers-institutes/embryonic-cell-gene-therapy-center/about.cfm |title= About Us |publisher= Center for Embryonic Cell and Gene Therapy |accessdate= March 4, 2015}}</ref>


==Early life==
==Early life==

Revision as of 04:56, 4 October 2021

Shoukhrat Mitalipov
Born1961 (age 62–63)
Almaty, Kazakh SSR, USSR
CitizenshipAmerican[1]
Alma materTimiryazev Agricultural Academy
Research Centre of Medical Genetics
OccupationScientist
Known forStem cell breakthrough

Shoukhrat Mitalipov (Shoe-KHRAHT Mee-tuhl-EE-pov, Russian: Шухрат Музапарович Миталипов;[2] born 1961)[3] is an American biologist who heads the Center for Embryonic Cell and Gene Therapy at the Oregon Health & Science University in Portland.[4] He is a well known pioneer of many nuclear transplantation studies and was named in 2013 by journal Nature as "the cloning chief".[citation needed] Mitalipov is also a godfather of a gene therapy, known as mitochondrial replacement therapy, that prevents inheritance of mitochondrial diseases. He discovered a new way of creating human stem cells from skin cells.[4][5]

Early life

Mitalipov was born in 1961 in Almaty, Kazakhstan, then part of the Soviet Union.[4] He is of Uyghur ancestry.[1] He served two years in Soviet military, beginning in 1979, as an army radio technician.[1]

Education

After the military, Mitalipov studied genetics at the Timiryazev Agricultural Academy in Moscow and also played blues guitar in a cover band to pay the bills.[4] After his graduation from the academy, he worked for a short time as the chief livestock specialist in a kolkhoz in the Yaroslavl region.[6] He received his master's degree in 1989.[4] He earned his PhD in developmental and stem cell biology from the Research Centre of Medical Genetics in Moscow.[4] After the fall of the Soviet Union in 1991 funding for stem cell research was scarce, so Mitalipov applied for and won a fellowship at Utah State University in 1995.[4] He started working at the Oregon National Primate Research Center in 1998, where he could work with monkeys, which share 98% of their DNA with humans; at Utah State Mitalipov had worked with cow DNA.[4]

Breakthroughs

A therapy for mitochondrial diseases that Mitalipov discovered, the "spindle transfer" technique, involves removing the nucleus from a human egg and placing it into another.[3][4] If the egg is fertilized, in genetic terms it would have three parents.[4] Mitalipov has successfully bred "three-parent" rhesus macaques.[4] The possibility of using the procedure on human eggs has raised safety and ethics questions.[4]

In May 2013, Mitalipov and his team published a study in Cell that describes a new process for creating human stem cells from skin cells.[5] The stem cell discovery made several journals' "Top 10" scientific breakthrough lists in 2013, including Nature, Science, Time, Discover, National Geographic and The Week.[5]

In August 2017, Mitalipov's collaborative work with the Institute for Basic Science, Salk Institute for Biological Studies, Seoul National University, BGI-Shenzhen and BGI-Qingdao, was published in Nature.[7] performed the first known successful attempt at genetically correcting mutant human embryos, using the CRISPR/Cas9 gene modifying tool.

Mitalipov and his team experimented upon a larger number of human embryos carrying a genetic defect causing heart disease. They demonstrated the possibility of safely and efficiently correcting the defective gene that cause inherited heart disease.[8]

Honors and awards

  • 1995 – Fellowship award, Exchange Visitor Program "Cooperation in Applied Sciences and Technologies (CAST)". Development of culture system to maintain pluripotency of bovine embryonic stem cells. Utah State University.
  • 2010 – Recipient of the 2010 Discovery Award, The Medical Research Foundation of Oregon
  • 2010 – Recipient of 2010 Women's Health Research Award, the Center for Women's Health, Circle of Giving
  • 2013 – Recognized by journal Nature as top 10 people who mattered in 2013
  • 2017 – Recipient of "Thousand Talents Plan" Award in China in the category of the Recruitment Program for Foreign Experts[9]

See also

References

  1. ^ a b c Budnick, Nick (June 2, 2013). "Oregon Stem-cell Groundbreaker Stirs International Frenzy with Cloning Advance". The Oregonian. Retrieved March 4, 2015.
  2. ^ Ученый из Казахстана первый в мире создал обезьяну-мутанта – новости науки | Tengrinews (in Russian)
  3. ^ a b Tavernise, Sabrina (March 17, 2014). "His Fertility Advance Draws Ire". The New York Times. Retrieved March 4, 2015.
  4. ^ a b c d e f g h i j k l Moore, Elizabeth Armstrong (September 17, 2014). "Splice of Life". Willamette Week. p. 12. Retrieved March 4, 2015.
  5. ^ a b c "About Us". Center for Embryonic Cell and Gene Therapy. Retrieved March 4, 2015.
  6. ^ Астахова, Алла (August 12, 2017). "Тонкая работа". Блог о здравоохранении (in Russian).
  7. ^ Ma, Hong; Marti-Gutierrez, Nuria; Park, Sang-Wook; Wu, Jun; Lee, Yeonmi; Suzuki, Keiichiro; Koski, Amy; Ji, Dongmei; Hayama, Tomonari; Ahmed, Riffat; Darby, Hayley; Van Dyken, Crystal; Li, Ying; Kang, Eunju; Park, A.-Reum; Kim, Daesik; Kim, Sang-Tae; Gong, Jianhui; Gu, Ying; Xu, Xun; Battaglia, David; Krieg, Sacha A.; Lee, David M.; Wu, Diana H.; Wolf, Don P.; Heitner, Stephen B.; Carlos Izpisua Belmonte, Juan; Amato, Paula; Kim, Jin-Soo; Kaul, Sanjiv; Mitalipov, Shoukhrat (2017). "Correction of a pathogenic gene mutation in human embryos". Nature. 548: 413–419. doi:10.1038/nature23305. PMID 28783728.
  8. ^ Connor, Steve. "First human embryos edited in U.S., using CRISPR". MIT Technology Review. Retrieved February 17, 2019.
  9. ^ People, Oregon Health & Science University. "Shoukhrat Mitalipov, PhD | OHSU People". Oregon Health & Science University. Retrieved March 25, 2019.

External links

Retrieved from "https://en.wikipedia.org/w/index.php?title=Shoukhrat_Mitalipov&oldid=1048084900"