Alexander van Oudenaarden
Alexander van Oudenaarden (born March 19, 1970 in Zuidland ) is a Dutch systems biologist and biophysicist.
Van Oudenaarden studied at the TU Delft with a degree in engineering (materials science) and physicist (1993) and received his doctorate in experimental solid state physics (Quantum vortices and quantum interference effects in circuits of small tunnel junctions) in 1998. As a post-graduate student , he was at Stanford University as a biochemist and biophysicist. In 2000 he became an assistant professor and later professor at the Massachusetts Institute of Technology . In 2012 he became Director of the Hubrecht Institute of the Dutch Academy of Sciences and Professor of Quantitative Biology of Gene Regulation at the University of Utrecht.
He dealt with the dynamics of actin and stochasticity and noise in gene networks and in gene expression, and he uses interdisciplinary methods (quantitative light microscopy, gene sequencing, etc.) to investigate how cells make robust "decisions" against the background of stochastic fluctuations in gene expression .
In 2017 he received the Spinoza Prize and was elected to the European Molecular Biology Organization . In 2012 and 2017 he received an ERC Advanced Grant. In 2014 he became a member of the Dutch Academy of Sciences and in 2015 of the Koninklijke Hollandsche Maatschappij der Wetenschappen. He received an NSF Career Award and was a Sloan Fellow and Guggenheim Fellow.
Fonts (selection)
- with M. Thattai: Intrinsic noise in gene regulatory networks, Proc. Nat. Acad. Sci. USA, Volume 98, 2001, p. 8614
- with E. Ozbudak, M. Thattai, I. Kurtser, AD Grossman: Regulation of noise in the expression of a single gene, Nature Genetics, Volume 31, 2002, p. 69
- with EM Ozbudak, M. thattai, HN Lim, BI Shraiman: Multistability in the lactose utilization network of Escherichia coli, Nature, Volume 427, 2004, pp. 737.-740
- with JM Pedraza: Noise propagation in gene networks, Science, Volume 307, 2005, pp. 1965-1969
- with M. Acar, A. Becskei: Enhancement of cellular memory by reducing stochastic transitions, Nature, Volume 435, 2005, p. 228
- with HN Lim: A multistep epigenetic switch enables the stable inheritance of DNA methylation states, Nature Genetics, Volume 39, 2007, pp. 269-275
- with JR Chabot, JM Pedraza, P. Luitel: Stochastic gene expression out-of-steady-state in the cyanobacterial circadian clock, Nature, Volume 450, 2007, pp. 1249-1252
- with A. Raj: Nature, nurture, or chance: stochastic gene expression and its consequences, Cell, Volume 135, 2008, pp. 216–226
- with A. Raj, P. Van Den Bogaard, SA Rifkin, S. Tyagi: Imaging individual mRNA molecules using multiple singly labeled probes, Nature methods, Volume 5, 2008, p. 877
- with M. Acar, JT Mettetal: Stochastic switching as a survival strategy in fluctuating environments, Nature Genetics, Volume 40, 2008, pp. 471-475
- with S. Mukherji: Synthetic biology: Understanding biological design from synthetic circuits, Nature Review Genetics, Volume 10, 2009, pp. 859-871
- with AM Khalil, John Rinn a. a .: Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression, Proc. Nat. Acad. Sci., Vol. 106, 2009, pp. 11667-11672
- with G. Balázsi, JJ Collins: Cellular decision-making and biological noise: from microbes to mammals, Cell, Volume 144, 2011, pp. 910-925
- with G. Neuert, B. Munsky, RZ Tan, L. Teytelman, M. Khammash: Systematic identification of signal-activated stochastic gene regulation, Science, Volume 339, 2013, pp. 584-587
Web links
| personal data | |
|---|---|
| SURNAME | Oudenaarden, Alexander van |
| BRIEF DESCRIPTION | Dutch systems biologist and biophysicist |
| DATE OF BIRTH | March 19, 1970 |
| PLACE OF BIRTH | Zuidland |