Allosteric center

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An allosteric or regulatory center is a region of an enzyme that can bind a regulator that, as an allosteric activator or inhibitor, influences enzyme activity . The binding of the allosteric regulator leads to a change in conformation of the enzyme, which affects the active center and thus leads to activation or inhibition of the enzyme. In contrast to competitive inhibition , the allosteric center is spatially separated from the active center and is often located in a different domain or subunit of the enzyme.

literature

  • H. Robert Horton, Laurence A. Moran, K. Gray Scrimgeour, J. David Rawn, Marc D. Perry: Biochemistry . 4th edition. Pearson Education, 2008, ISBN 978-3-8273-7312-0 , pp. 204 .